| Identification | More | [Name]
5-Methoxyisatin | [CAS]
39755-95-8 | [Synonyms]
5-METHOXY-2,3-INDOLINEDIONE
5-METHOXYINDOLE-2,3-DIONE
5-METHOXYISATIN
AKOS AU36-M122
5-methoxy-1h-indole-2,3-dione
5-methoxy-1h-indole-3-dione
5-methoxy-indole-3-dione
5-Methoxyisatin,98%
5-Methoxy-2H-indole-2,3(1H)-dione | [EINECS(EC#)]
670-372-2 | [Molecular Formula]
C9H7NO3 | [MDL Number]
MFCD00169023 | [Molecular Weight]
177.16 | [MOL File]
39755-95-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
201-203°C | [density ]
1.346±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
9.73±0.20(Predicted) | [color ]
Orange to Amber to Dark red | [Water Solubility ]
Soluble in cold water. | [Detection Methods]
HPLC,NMR | [CAS DataBase Reference]
39755-95-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RTECS ]
NL7938000 | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Dark red to brown solid | [Uses]
5-Methoxyisatin is used for Pharmaceutical intermediates, a raw material used in chemical synthesis. | [Definition]
ChEBI: 5-Methoxyisatin is a member of indoles. It has a role as an anticoronaviral agent. | [Preparation]
Using water as solvent, 5-methoxyaniline reacted with chloral hydrate and hydroxylamine hydrochloride at 90 ℃ for 3.5h to obtain p-methoxyisonitrosoacetanilide in 95% yield. After hydrolysis, 5-methoxyisatin was obtained in 88% yield by cyclization at 92℃ with concentrated H2SO4 (75%). | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 42, p. 1344, 1977 DOI: 10.1021/jo00428a016 |
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