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ChemicalBook--->CAS DataBase List--->37661-08-8

37661-08-8

37661-08-8 Structure

37661-08-8 Structure
IdentificationBack Directory
[Name]

BACAMPICILLIN HYDROCHLORIDE
[CAS]

37661-08-8
[Synonyms]

bapc
ambaxin
bacacil
Pengood
penglobe
ambacamp
Spectrobid
Bacampicine
becampicillin
Bacampicillin HCl
BECAMPICILLINHYDROCHLORIDE
BACAMPICILLIN HYDROCHLORIDE
IWVTXAGTHUECPN-ANBBSHPLSA-N
Bacampicilline Hydrochloride
Bacampicillin hydrochloride CRS
Bacampicillin Hydrochloride (200 mg)
BACAMPICILLIN HYDROCHLORIDE USP/EP/BP
Bacampicillin Hydrochloride (1047300)
BACAMPICILLIN HYDROCHLORIDE EP STANDARD
BACAMPICILLIN HYDROCHLORIDE USP STANDARD
o)-3,3-dimethyl-7-oxo-,1-((ethoxycarbonyl)oxy)ethylester,hydrochloride
(2S,5R,6R)-1-((ethoxycarbonyl)oxy)ethyl 6-((R)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrochloride
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-, 1-[(ethoxycarbonyl)oxy]ethyl ester, monohydrochloride, (2S,5R,6R)-
1-[(ethoxycarbonyl)oxy]ethyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, 1-[(ethoxycarbonyl)oxy]ethyl ester, monohydrochloride, [2S-[2α,5α,6β(S*)]]-
[EINECS(EC#)]

253-580-4
[Molecular Formula]

C21H28ClN3O7S
[MDL Number]

MFCD00133117
[MOL File]

37661-08-8.mol
[Molecular Weight]

501.98
Chemical PropertiesBack Directory
[Appearance]

White or almost white powder or granules, hygroscopic.
[Melting point ]

171-176° (dec)
[alpha ]

D20 +161.5°
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in water, freely soluble in ethanol (96 per cent), soluble in methylene chloride.
[form ]

neat
[color ]

Crystals from Me2CO pet ether
Hazard InformationBack Directory
[Chemical Properties]

White or almost white powder or granules, hygroscopic.
[Uses]

Bacampicillin is a penicillin class of antibiotic. Bacampicillin is a prodrug of ampicillin (A634300) with improved oral bioavailability.
[Definition]

ChEBI: The hydrochloride salt of bacampicillin.
[Brand name]

Spectrobid (Pfizer).
[Description]

Bacampicillin was synthesized by Ekstrom¨ et al. of Astra Lakemedel in 1975. It is ¨ more stable against acid than ampicillin and more rapidly absorbed orally; its absorption is less affected by a patient’s most recent meal than is the case for ampicillin. Bacampicillin is hydrolyzed by intestinal esterase after oral administration and then behaves the same as ampicillin. In double-blind comparison studies, bacampicillin was shown to be as effective as ampicillin when administered at half the dose.
[Originator]

Penglobe,Astra,W. Germany,1977
[Manufacturing Process]

1'-Ethoxycarbonyloxyethyl 6-(D-α-azidophenylacetamido)penicillinate (98 g) was prepared from sodium 6-(D-α-azidophenylacetamido)penicillinate (397 g, 1 mol), α-chlorodiethylcarbonate (458 g, 3 mols) and sodium bicarbonate (504 g, 6 mols). The product showed strong IR absorption at 2090 cm-1 and 1780-1750 cm-1 showing the presence of azido group and β-lactam and ester carbonyls.
It was dissolved in ethyl acetate (700 ml) and hydrogenated at ambient conditions over a palladium (5%)on carbon catalyst (18 g). The catalyst was removed by filtration and washed with ethyl acetate. The combined filtrates were extracted with water at pH 2.5 by addition of dilute hydrochloric acid. Lyophilization of the aqueous phase gave the hydrochloride of 1'- ethoxycarbonyloxyethyl 6-(D-α-aminophenylacetarnido)penicillinate (94 g), MP 171°-176°C.
[Therapeutic Function]

Antibacterial
[Clinical Use]

Bacampicillin hydrochloride (Spectrobid) is the hydrochloridesalt of the 1-ethoxycarbonyloxyethyl ester of ampicillin.It is a prodrug of ampicillin with no antibacterial activity.After oral absorption, bacampicillin is hydrolyzed rapidly byesterases in the plasma to form ampicillin.
Oral absorption of bacampicillin is more rapid and completethan that of ampicillin and less affected by food.Plasma levels of ampicillin from oral bacampicillin exceedthose of oral ampicillin or amoxicillin for the first 2.5 hoursbut thereafter are the same as for ampicillin and amoxicillin.49 Effective plasma levels are sustained for 12 hours,allowing twice-a-day dosing.
[Safety Profile]

Poison by intraperitoneal andintravenous routes. Mildly toxic by ingestion andsubcutaneous routes. When heated to decomposition itemits very toxic fumes of NOx, SOx, and HCl.
[storage]

Store at -20°C
Safety DataBack Directory
[Toxicity]

LD50 in mice (mg/kg): 8529 orally; 176 i.p.; 9475 s.c.; 184 i.v. (Edanaga)
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