| Identification | More | [Name]
Budralazine | [CAS]
36798-79-5 | [Synonyms]
1-(2-(1,3-DIMETHYL-2-BUTENYLIDENE)HYDRAZINO)PHTHALAZINE
1,2-DIHYDROPHTHALAZIN-1-ONE
1(2H)-PHTHALAZINONE
1,2H-PHTHALAZONE
1,3-DIHYDRO-4-KETO-2 3-BENZODIAZINE
BENZO[D]PYRIDAZIN-1(2H)ONE
BUDRALAZINE
DIHYDROOXOPHTHALAZINE
PHTHALAZONE
PTLZ
1-[2-(1,3-Dimethyl-2-buten-1-ylidene)hydrazino]phthalazine
4-Methyl-3-penten-2-one (phthalazin-1-yl)hydrazone
Buterazine
DJ-1461 | [EINECS(EC#)]
204-319-8 | [Molecular Formula]
C8H6N2O | [MDL Number]
MFCD00006892 | [Molecular Weight]
146.15 | [MOL File]
36798-79-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
183-185 °C(lit.) | [Boiling point ]
373.02°C (rough estimate) | [density ]
1.1506 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [color ]
Light Yellow to Yellow | [Stability:]
Light Sensitive | [CAS DataBase Reference]
36798-79-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
TH9185000
| [Toxicity]
LD50 in mice, rats (mg/kg): 1820, 620 orally; 4020, 3570 i.p. (Onodera) |
| Hazard Information | Back Directory | [Description]
Budralazine is an antihypertensive agent which is somewhat less potent than
structurally related hydralazine, and reportedly produces less tachycardia. | [Originator]
Daiichi (Japan) | [Uses]
Budralazine a new antihypertensive agent. Budralazine is a direct-acting vasodilator. | [Definition]
ChEBI: Budralazine is a member of phthalazines. | [Manufacturing Process]
A mixture of 2.0 g of 1-hydrazinophthalazine hydrochloride, 1.1 g of mesityl
oxide (isoproplyideneacetone) and 100 ml of ethanol, was refluxed for 3
hours. The reaction mixture was concentrated in vacuo and the residue was dissolved in water. The water solution was neutralized with sodium
bicarbonate, salted out and the product was extracted with benzene. The
benzene layer was passed through a comparatively short column of alumina
and the solvent was removed. The residue was crystallized from ether to give
0.7 g of 1-(1,3-dimethyl-2-butenylidene) hydrazinophthalazine, melting point
131°-132°C. | [Brand name]
BUTERAZINE | [Therapeutic Function]
Antihypertensive |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|