| Identification | More | [Name]
2-Chloro-4-picoline | [CAS]
3678-62-4 | [Synonyms]
2-CHLORO-4-METHYLPYRIDINE
2-CHLORO-4-PICOLINE
2-CHLORO-GAMMA-PICOLINE
2-CHLOROPICOLINE
4-Picoline, 2-chloro-
Pyridine, 2-chloro-4-methyl-
2-chloro-4-methylpyrdine
2-Chloro-4-methylpyridine(2-Chloropicoline)
2-CHLORO-4-PICOLINE 2-CHLORO-4-METHYLPYRIDINE
2-CHLORO-4-METHYLPYRIDINE (2-CHLORO-4-PICOLINE)
HCPY1902-Chloro-4-picoline | [EINECS(EC#)]
222-951-2 | [Molecular Formula]
C6H6ClN | [MDL Number]
MFCD00023418 | [Molecular Weight]
127.57 | [MOL File]
3678-62-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liquid. | [Melting point ]
115°C | [Boiling point ]
194-195 °C (lit.) | [density ]
1.456 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.529(lit.)
| [Fp ]
193 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Liquid | [pka]
0.94±0.10(Predicted) | [color ]
Clear colorless to light yellow | [Specific Gravity]
1.14 | [CAS DataBase Reference]
3678-62-4(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Cl-4-(CH3)-pyridine(3678-62-4) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT, IRRITANT-HARMFUL | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liquid. | [Uses]
2-Chloro-4-methylpyridine is used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines as potential antipsychotics. It is also used in the preparation of trifluoromethyl(pyrimidinyl)azetidinecarboxamides as potent, orally bioavailable TGR5 agonists. | [General Description]
2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction. |
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