| Identification | Back Directory | [Name]
API-2 | [CAS]
35943-35-2 | [Synonyms]
TCN
IAP1
MIHC
MYHL
BBMI
MYO1A
RNF49
BIRC3
API-2
nosyl-
DFNA48
3-amine
VD-0002
hthylene
uranosyl-
Myosin-Ia
Anti-Myhl
NSC 154020
Inhibitor V
TRICIRIBINE
Anti-Dfna48
Anti-Myosin ia
AKT INHIBITOR V
API-2 (Tricirbine)
Triciribine hydrate
TRICYCLIC NUCLEOSIDE
pentaazacentopthylene
Brush border myosin I
AKT/PKB SIGNALING INHIBITOR-2
Anti-MYO1A antibody produced in rabbit
ANTI-MYO1A (CENTER S291) antibody produced in rabbit
ANTI-CIAP2 (BIRC3)(N-TERMINAL) antibody produced in rabbit
4,5,6,8-pentaazaacenaphthylen-5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1
1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof
3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1,4,5,6,8-pentaazaacenap
1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura
1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
(1,4,5,6,8-Pentaazaacenaphthylen-3-aMine,1,5-dihydro-5-Methyl-1-b-D-ribofuranosyl-)
1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE
6-AMino-4-Methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyriMido[4,5-c]pyridazine
6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE
Triciribine
1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Triciribine
(2R,3R,4S,5R)-2-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol | [Molecular Formula]
C13H16N6O4 | [MDL Number]
MFCD00932413 | [MOL File]
35943-35-2.mol | [Molecular Weight]
320.3 |
| Chemical Properties | Back Directory | [Melting point ]
207 °C (decomp) | [Boiling point ]
459.21°C (rough estimate) | [density ]
1.2633 (rough estimate) | [refractive index ]
1.7000 (estimate) | [storage temp. ]
Store at RT | [solubility ]
DMSO: >10mg/mL | [form ]
powder | [pka]
12.35±0.70(Predicted) | [color ]
tan | [InChIKey]
HOGVTUZUJGHKPL-HTVVRFAVSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Usage]
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al
so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO. | [Biological Activity]
Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and-2. | [Uses]
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al
so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO. | [Definition]
ChEBI: Triciribine is a nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. | [Biochem/physiol Actions]
Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. | [storage]
Store at -20°C |
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