| Identification | More | [Name]
5-NITROSO-8-HYDROXYQUINOLINE | [CAS]
3565-26-2 | [Synonyms]
5-NITROSO-8-HYDROXYQUINOLINE
5-NITROSO-8-QUINOLINOL
5-NITROSO-OXINE
8-HYDROXY-5-NITROQUINOLINE
8-HYDROXY-5-NITROSOQUINOLINE
NSC 3852
5-Nitroso-8-cinnolinol
5-nitroso-8-quinolino
8-Quinolinol, 5-nitroso-
Hydron III
hydroniii
RMH-79
5-nitrosoquinolin-8-ol
5-NITROSO-8-HYDROXYQUINOLINE 95+% | [EINECS(EC#)]
222-650-6 | [Molecular Formula]
C9H6N2O2 | [MDL Number]
MFCD00041862 | [Molecular Weight]
174.16 | [MOL File]
3565-26-2.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R5:Heating may cause an explosion.
R40:Limited evidence of a carcinogenic effect.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves . | [Toxicity]
mmo-sat 1 mmol/plate MUREAV 164,263,86 |
| Hazard Information | Back Directory | [Chemical Properties]
slightly yellow to yellow-green powder | [Uses]
5-NITROSO-8-HYDROXYQUINOLINE is shown to have cell differentiation and antiproliferative activity in human breast cancer cells in tissue culture and antitumor activity in mice bearing P388 and L1210 leukemic cells. | [Definition]
ChEBI: 5-nitroso-8-quinolinol is a hydroxyquinoline. | [Biological Activity]
Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo . | [Safety Profile]
Poison by intravenous and intraperitoneal routes. Many nitroso compounds are carcinogens. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | [storage]
Store at RT | [References]
[1]. martirosyan a, leonard s, shi x, et al. actions of a histone deacetylase inhibitor nsc3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in mcf-7 human mammary tumor cells. j pharmacol exp ther, 2006, 317(2): 546-552.
[2]. strobl js, seibert cw, li y, et al. inhibition of toxoplasma gondii and plasmodium falciparum infections in vitro by nsc3852, a redox active antiproliferative and tumor cell differentiation agent. j parasitol, 2009, 95(1): 215-223. |
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