| Identification | More | [Name]
beta-Guanidinopropionic acid | [CAS]
353-09-3 | [Synonyms]
3-Guanidinopropanoate
3-GUANIDINOPROPIONIC ACID
BETA-GUANADINOPROPIONIC ACID
BETA-GUANIDINOPROPIONIC ACID
B-GUANIDINO PROPIONIC ACID
DL-BETA-GUANIDINO PROPIONIC ACID
GUANIDINO PROPANOIC ACID
N-(AMINOMETHYL)-BETA-ALANINE
3-guanidinopropanoicacid
guanidinepropanoicacid
guanidinopropionicacid
n-(aminoiminomethyl)-beta-alanin
n-(aminoiminomethyl)beta-alanine
n-amidino-beta-alanin
Β-GUANIDINOPROIONIC ACID 99% BIOTECH GRADE
GuanidinoPropionicAcid(Gpa)
Gpa(BuanidinopropionicAcid)
Gpa (B–Guanidinopropionic Acid)
Guanidine propionate
BCGUANIDINOPROPIONIC ACID | [EINECS(EC#)]
206-530-0 | [Molecular Formula]
C4H9N3O2 | [MDL Number]
MFCD00045939 | [Molecular Weight]
131.13 | [MOL File]
353-09-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
222 °C (dec.)(lit.)
| [Boiling point ]
299.1±42.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Aqueous Acid (Slightly), Water (Slightly, Heated) | [form ]
Solid | [pka]
4.22±0.10(Predicted) | [color ]
White to Off-White | [Detection Methods]
NMR | [BRN ]
1705262 | [LogP]
-1.680 (est) | [CAS DataBase Reference]
353-09-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
AY3157500
| [HS Code ]
29252900 |
| Hazard Information | Back Directory | [Description]
Guanidinopropionic acid is a white crystal that dissolves in water and is a creatine analog. Guanidinopropionic acid is a kind of amino acid derivatives. It is an important chemical raw material and intermediate. It exists in the serum, brain, liver, kidney and urine of mammals. It can improve insulin sensitivity and selectively reduce Adipose tissue weight can treat and prevent metabolic disorders, hyperglycemia, hyperinsulinemia, insensitivity to blood insulin, hyperlipidemia, hyperamylase, obesity and other symptoms. | [Chemical Properties]
White solid | [Uses]
3-Guanidinopropionic Acid is an acidic guanidine derivative that has been shown to ameliorate hyperglycemia in animal models of noninsulin-dependent diabetes. | [Definition]
ChEBI: A guanidine compound bearing an N-(2-carboxyethyl) substituent. It is a creatine analogue that has been found to decreases plasma glucose levels | [Synthesis]
Using thiourea |?-alanine as a raw material, guanidinopropionic acid is prepared by a two-step alkylation reaction of nucleophilic substituted amine, the content is greater than 99.0%, and the total yield is 76.2%. The process is low cost, mild conditions, and easy operation, simple and suitable for industrial production.
 | [References]
[1] winder w w, hardie d g. amp-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes[j]. american journal of physiology-endocrinology and metabolism, 1999, 277(1): e1-e10.
[2] chaturvedi, r. k.,adhihetty, p.,shukla, s., et al. impaired pgc-1α function in muscle in huntington’s disease. human molecular genetics 18(16), 3048-3065 (2009).
[3] larsen s d, connell m a, cudahy m m, et al. synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent[j]. journal of medicinal chemistry, 2001, 44(8): 1217-1230.
[4] meglasson m d, wilson j m, yu j h, et al. antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic kkay and c57bl6job/ob mice and increases glucose disappearance in rhesus monkeys[j]. journal of pharmacology and experimental therapeutics, 1993, 266(3): 1454-1462. |
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