| Identification | More | [Name]
L-CYCLOSERINE | [CAS]
339-72-0 | [Synonyms]
H-CYCLOSERINE
L-4-AMINO-3-ISOOXAZOLIDINONE
L-4-AMINO-3-ISOXALOLIDINONE
L-4-AMINO-3-ISOXAZOLIDINONE
L-CYCLOSERINE
S(-)-4-AMINO-3-ISOXAZOLIDINONE
(S)-4-AMINO-3-ISOXAZOLIDONE
(l)-3-isoxazolidinon
(s)-3-isoxazolidinon
Levcycloserine
L-4-aminoisoxazolidin-3-one
(S)-(-)-CYCLOSERINE, 97%
L-CYCLOSERIN
3-Isoxazolidinone, 4-amino-, (4S)-
3-Isoxazolidinone, 4-amino-, (S)-
Cyclo-L-serine
3-Isoxazolidinone,4-amino-,(4S)-(9CI)
(S)-4-Amino-3-isoxazolidone, L-4-Amino-3-isoxazolidinone, L-Cycloserine, L-cycloserine
(4S)-4-Aminoisoxazolidin-3-one
(S)-4-Aminoisoxazolidin-3-one | [EINECS(EC#)]
206-427-0 | [Molecular Formula]
C3H6N2O2 | [MDL Number]
MFCD00064324 | [Molecular Weight]
102.09 | [MOL File]
339-72-0.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE GRANULAR POWDER | [Melting point ]
147 °C | [Boiling point ]
191.38°C (rough estimate) | [density ]
1.278 | [refractive index ]
1.5110 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
H2O: soluble50mg/mg protein | [form ]
White to off-white powder. | [pka]
14.36±0.40(Predicted) | [BRN ]
80799 | [CAS DataBase Reference]
339-72-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R5:Heating may cause an explosion.
R20:Harmful by inhalation. | [Safety Statements ]
S38:In case of insufficient ventilation, wear suitable respiratory equipment .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
2
| [RTECS ]
NY2976000
| [F ]
10 |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE GRANULAR POWDER | [Uses]
antibacterial, coccidiostat | [Uses]
L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase. | [Definition]
ChEBI: A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora. | [Biochem/physiol Actions]
L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis. | [Purification Methods]
Purify cycloserine by recrystallisation from aqueous EtOH or MeOH or aqueous NH3/EtOH or isoPrOH. Also recrystallise it from aqueous ammoniacal solution at pH 10.5 (100mg/mL) by diluting with 5 volumes of isopropanol and then adjusting to pH 6 with acetic acid. An aqueous solution, buffered to pH 10 with Na2CO3, can be stored in a refrigerator for 1week without decomposition. UV: max at 226nm (A1cm 1% 4.02). The tartrate salt has m 165-166o (dec), 166-168o (dec), and [] D 24 -41o (c 0.7, H2O). [Stammer et al. J Am Chem Soc 79 3236 1959, UV: Kuehl J Am Chem Soc 77 2344 1955, Beilstein 27 III/IV 5549.] |
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