| Identification | Back Directory | [Name]
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE | [CAS]
29734-68-7 | [Synonyms]
DHβE hydrobromide
-erythroidineHydrobromide
-erythroidine hydrobromide
Dihydro-2-erythroidine Hydrobromide
Dihydro-β-erythroidine hydrobromide
DIHYDRO-B-ERYTHROIDINE HYDROBROMIDE
Dihydro-β-erythroidine hydrobromide
DIHYDRO-BETA-ERYTHROIDINE HYDROBROMIDE
DIHYDRO-B-ERYTHROIDINE HYDROBROMIDE COMP ETITIVE NICOTINIC
3β-1,6-Didehydro-14,17-dihydro-3-methoxy-16(15H)-oxaerythrinan-15-one hydrobromide
3BETA-1,6-DIDEHYDRO-14,17-DIHYDRO-3-METHOXY-16(15H)-OXAERYTHRINAN-15-ONE HYDROBROMIDE
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
1H,12H-Pyrano[4',3':3,4]pyrido[2,1-i]indol-12-one, 2,3,5,6,8,9,10,13-octahydro-2-methoxy-, hydrobromide (1:1), (2S,13bS)- | [Molecular Formula]
C16H21NO3.BrH | [MDL Number]
MFCD00153793 | [MOL File]
29734-68-7.mol | [Molecular Weight]
356.25 |
| Hazard Information | Back Directory | [Uses]
Dihydro-β-erythroidine is an alkaloid isolated from the seeds of erythrina and a competitive antagonist at the nicotinic acetylcholine receptor (nAChR). | [Definition]
ChEBI: Dihydro-beta-erythroidine hydrobromide is a member of indoles. | [Biological Activity]
Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α 4 receptor subunit (IC 50 values are 0.19 and 0.37 μ M for α 4 β 4 and α 4 β 2 receptors respectively). Antagonizes behavioral effects of nicotine in vivo . | [in vitro]
dhβe has been shown to be a purely competitive antagonist of the neuronal nicotinic receptor [1]. | [in vivo]
dhβe is able to block some of the central actions of nicotine after systemic and intrathecal administration. the mechanism of blockade is different from that of mecamylamine, a classical ganglionic antagonist, and may involve a direct action of dhβe on nicotine receptor [2]. | [IC 50]
1.3 μm for α2β2, 2.3 μm for α2β4, 0.41 μm for α3β2, 23.1 μm for α3β4, 0.37 μm for α4β2, and 0.19 μm for α4β4 [1] | [storage]
Desiccate at RT | [References]
[1] harvey sc, maddox fn, luetje cw. multiple determinants of dihydro-beta-erythroidine sensitivity on rat neuronal nicotinic receptor alpha subunits. j neurochem. 1996 nov;67(5):1953-9.
[2] damaj mi, welch sp, martin br. in vivo pharmacological effects of dihydro-beta-erythroidine, a nicotinic antagonist, in mice. psychopharmacology (berl). 1995 jan;117(1):67-73.
[3] murphree hb. effects in human volunteers of subparalytic doses of dihydro-beta-erythroidine. clin pharmacol ther. 1963 may-jun;4:304-10. |
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