| Identification | More | [Name]
2-Chloronicotinic acid | [CAS]
2942-59-8 | [Synonyms]
2-CHLORO-3-PYRIDINECARBOXYLIC ACID
2-CHLORONICOTINIC ACID
2-CHLOROPYRIDIN-3-CARBOXYLIC ACID
2-CHLOROPYRIDINE-3-CARBOXYLIC ACID
2CLNA
AKOS BBS-00004231
CHLORONICOTINIC ACID
RARECHEM AL BO 0287
TIMTEC-BB SBB004002
2-chloro-3-pyridinecarboxylicaci
3-Pyridinecarboxylic acid, 2-chloro-
2-ChloroNicotinicAcid,99%-100.5%
2-CHLORO-3-CARBOXYLPYRIDINE
2-Chloropyridine-3-carboxylic
2-Chloronicotinic acid 98%
2-Chloro Nicotinc Acid
2-CHLORO-3-PYRIDINECARBOXYLIC ACID/2-CHLORONICOTINIC ACID
2-CHLORONICOTINIC ACID 2-CHLOROPYRIDIN-3-CARBOXYLIC ACID
2-CHLORONITINICACID | [EINECS(EC#)]
220-937-0 | [Molecular Formula]
C6H4ClNO2 | [MDL Number]
MFCD00006236 | [Molecular Weight]
157.55 | [MOL File]
2942-59-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White to cream powder | [Melting point ]
176-178 °C (dec.)(lit.)
| [Boiling point ]
316.8±22.0 °C(Predicted) | [density ]
1.470±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO, Ethyl Acetate (Slightly) | [form ]
Powder | [pka]
2.07±0.25(Predicted) | [color ]
White to cream | [Detection Methods]
HPLC | [BRN ]
119023 | [InChI]
InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10) | [InChIKey]
IBRSSZOHCGUTHI-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=CC=C1C(O)=O | [LogP]
0.988 | [CAS DataBase Reference]
2942-59-8(CAS DataBase Reference) | [EPA Substance Registry System]
2942-59-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
T | [HazardClass ]
IRRITANT | [HS Code ]
29333999 |
| Hazard Information | Back Directory | [Chemical Properties]
White to cream powder | [Uses]
2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity. | [Application]
2-Chloronicotinic acid is used in the synthesis of the anti-inflammatory and analgesic pralofen. It is an intermediate of the herbicides nicosulfuron and diflufenican. It is also used as pharmaceutical intermediates for the manufacture of mefenamic acid, niflumic acid, etc. | [Definition]
ChEBI: 2-Chloronicotinic acid is an aromatic carboxylic acid and a member of pyridines. | [Preparation]
Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid. |
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