Identification | Back Directory | [Name]
15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE | [CAS]
2623-22-5 | [Synonyms]
15-mas NSC-267030 deacetylanguidin Desacetylanguidine 15-ACETOXYSCIRPENOL monoacetoxyscirpenol 15-ACETOXYSCIRPENDIOL 15-MONOACETYLSCIRPENOL 15-MONOACETOXYSCIRPENOL 12,13-Epoxytrichothec-9-ene-3α,4β,15-triol 15-acetate 15-acetoxy-3α,4β-dihydroxy-12,13-epoxytrichothec-9-ene 3α,4β-Dihydroxy-15-acetoxy-12,13-epoxytrichotheca-9-ene Anguidine, desacetyl(15-acetoxyscirpene-3,4-diol-bl5732) (3-alpha)-12,13-epoxytrichothec-9-ene-3,4,15-triol15-acetate 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE 4-beta,15-triol,12,13-epoxy-trichothec-9-ene-3-alph15-acetate Trichothec-9-ene-3.α.,4.β.,15-triol, 12,13-epoxy-, 15-acetate Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 15-acetate, (3α,4β)- Trichothec-9-ene-3.alpha.,4.beta.,15-triol, 12,13-epoxy-, 15-acetate Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 15-acetate, (3.alpha.,4.beta.)- 15-Acetoxyscirpendiol, 15-Acetoxy-3α,4β-dihydroxy-12,13-epoxytrichothec-9-ene 15 Acetoxyscirpenol (3alpha,4beta)-12,13-epoxy-trichothec-9-ene-3,4,15-triol 15-acetate ((2R,2S,3R,5R,5AR,9aR)-3-hydroxy-5,8-dimethyl-2,3,4,5,5a,6,7,9a-octahydrospiro[2,5-methanobenzo[b]oxepine-10,2-oxiran]-5a-yl)methyl acetate | [Molecular Formula]
C18H26O5 | [MDL Number]
MFCD00078774 | [MOL File]
2623-22-5.mol | [Molecular Weight]
322.4 |
Chemical Properties | Back Directory | [Melting point ]
170-172 °C | [Boiling point ]
465.5±45.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
≤10mg/ml in methanol;10mg/ml in dichloromethane | [form ]
powder | [pka]
13.72±0.70(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Chemical Properties]
Solid | [Hazard]
A poison by ingestion. A mild skin irritant. | [Uses]
15-Acetoxyscirpenol is a trichothecene mycotoxin and an apoptosis inducer. | [Biological Activity]
15-acetoxy scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the fusarium genus [1]. 15-acetoxy scirpenol could induce apoptotic cell death in human jurkat t cells. mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus fusarium. acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). the 50% inhibitory concentration (ic50) values of 15-acetoxy scirpenol was 16.1 ng/ml [2]. in the jurkat t cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-mas), the populations of externalized ps-positive and pi-negative cells were 32.0% [2]. | [References]
[1] peraica m, radic b, lucic a, et al. toxic effects of mycotoxins in humans[j]. bulletin of the world health organization, 1999, 77(9): 754-766. [2] lee d h, park t, kim h w. induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving parp in jurkat t cells through treatment with acetoxyscirpenol mycotoxins[j]. biological and pharmaceutical bulletin, 2006, 29(4): 648-654. |
Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
YD0111000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
29329990 |
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