| Identification | Back Directory | [Name]
1-Chloro-N,N,2-trimethylpropenylamine | [CAS]
26189-59-3 | [Synonyms]
Ghosez′s reagent
TETRAMETHYL-ALPHA-CHLORENAMINE
1-CHLORO-N,N,2-TRIMETHYLPROPENYLAMINE
(1-CHLORO-2-METHYLPROPENYL)DIMETHYLAMINE
1-CHLORO-N,N,2-TRIMETHYL-1-PROPENYLAMINE
1-chloro-N,N,2-trimethyl-1-Propen-1-amine
1-Chloro-N,N,2-trimethylpropenylamine ,98%
1-Chloro-N,N,2-triMethyl-1-propenylaMine 96%
1-Chloro-N,N,2-trimethylpropenylamine, 98.5+%
1-Chloro-N,N,2-triMethylpropenylaMine, 98.5+% 5ML | [Molecular Formula]
C6H12ClN | [MDL Number]
MFCD00800562 | [MOL File]
26189-59-3.mol | [Molecular Weight]
133.62 |
| Chemical Properties | Back Directory | [Appearance]
Colorless to yellow liquid | [Boiling point ]
129-130 °C(lit.)
| [density ]
1.01 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.453(lit.)
| [Fp ]
80 °F
| [storage temp. ]
Freezer (-20°C) | [form ]
Liquid | [pka]
4.27±0.70(Predicted) | [color ]
Colorless to yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to yellow liquid | [Uses]
1-Chloro-N,N,2-trimethyl-1-propenylamine is an acid halogenation reagent developed by Ghosez, that enables the conversion of carboxylic acids into the corresponding chlorides under strictly neutral conditions. This method was successfully used in the total synthesis of caloporoside, roseophilin, (-)-enniatin B, (±)-epimeloscine and (±)-meloscine. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 94, p. 2869, 1972 DOI: 10.1021/ja00763a061
Organic Syntheses, Coll. Vol. 6, p. 282, 1988
Tetrahedron Letters, 25, p. 5043, 1984 DOI: 10.1016/S0040-4039(01)91114-1 |
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