| Identification | More | [Name]
Clobetasone butyrate | [CAS]
25122-57-0 | [Synonyms]
(16-beta)-)
11,20-trione,21-chloro-9-fluoro-17-hydroxy-16-beta-methyl-pregna-4-diene-3
21-chloro-9-fluoro-17-hydroxy-16-beta-methylpregna-1,4-diene,3,11,20-trione
eumovate
molivate
pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy
sn203
21-chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
ClobetasolPropionate-Bp/Ep/Usp
Butyric acid, ester with 21-chloro-9-fluoro-17-hydroxy-16β-methylpregna-1,4-diene-3,11,20-trione (8CI)
CCl 5537
Emovate
GR 2/1214
Kindavate
Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16β)-
Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-17-hydroxy-16β-methyl-, butyrate (8CI)
21-Chloro-9-fluoro-17-hydroxy-16b-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
Clobetasone butyrate
Clobetasone-17-butyrate
CLOBETASOLE BUTYRATE | [EINECS(EC#)]
246-635-9 | [Molecular Formula]
C22H26ClFO4 | [MDL Number]
MFCD00133196 | [Molecular Weight]
408.891 | [MOL File]
25122-57-0.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white powder. | [Melting point ]
90-100° | [Boiling point ]
573.3±50.0 °C(Predicted) | [density ]
1.1736 (estimate) | [storage temp. ]
Refrigerator, Under Inert Atmosphere | [solubility ]
Practically insoluble in water, freely soluble in acetone and in methylene chloride, slightly soluble in ethanol (96 per cent). | [form ]
neat | [color ]
White to Off-White | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. | [InChIKey]
FBRAWBYQGRLCEK-JGSYYNBSNA-N | [SMILES]
[C@]1(C(=O)CCl)(OC(=O)CCC)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C |&1:0,11,14,16,26,28,33,r| | [CAS DataBase Reference]
25122-57-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [RTECS ]
TU4154083 | [HS Code ]
29372290 | [Toxicity]
mouse,LD50,intraperitoneal,500mg/kg (500mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983. |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white powder. | [Uses]
Glucocorticoid; anti-inflammmatory. | [Definition]
ChEBI:Clobetasone butyrate is an organic molecular entity. | [Mechanism of action]
Topical corticosteroids (Clobetasone butyrate) inhibit the migration of macrophages and leukocytes into areas of inflamed skin by reversing vascular dilation and permeability, resulting in decreased erythema, edema and pruritus. | [Side effects]
Some people get a burning or stinging feeling for a few minutes when they put clobetasone cream or ointment on their skin. Clobetasone cream contains cetostearyl alcohol and chlorocresol, which may cause local skin reactions or allergic reactions.
| [storage]
Store at -20°C |
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