| Identification | Back Directory | [Name]
PROTAC ER Degrader-4 | [CAS]
2361114-15-8 | [Synonyms]
PROTAC ER Degrader-4 | [Molecular Formula]
C53H67F3N6O8S | [MDL Number]
MFCD34469813 | [Molecular Weight]
1005.19 |
| Chemical Properties | Back Directory | [Boiling point ]
1038.9±65.0 °C(Predicted) | [density ]
1.254±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.54±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1].
PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1]. | [References]
[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1. |
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