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ChemicalBook--->CAS DataBase List--->223387-75-5

223387-75-5

223387-75-5 Structure

223387-75-5 Structure
IdentificationBack Directory
[Name]

FG 2216
[CAS]

223387-75-5
[Synonyms]

BIQ
FG2216
YM 311
FG-2216
FG 2216
CS-1687
FG-2216(IOX3
FG-2216 - YM 311
FG2216;FG-2216;FG 2216
FG 2216 (erythropoietic agent)
N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine
Glycine, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-
2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)acetic acid
[[(1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino]acetic acid
(N-(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino)-acetic acid
(Z)-2-(((1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)(HYDROXY)METHYLENE)AMINO)ACETIC ACID
[Molecular Formula]

C12H9ClN2O4
[MOL File]

223387-75-5.mol
[Molecular Weight]

280.66
Chemical PropertiesBack Directory
[Boiling point ]

670.6±55.0 °C(Predicted)
[density ]

1.571±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic
[form ]

powder
[pka]

3.20±0.10(Predicted)
[color ]

white to beige
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P305+P351+P338
Hazard InformationBack Directory
[Description]

FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 μM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.
[Uses]

FG 2216 is an erythropoietic agent which is orally active prolyl-hydroxylase inhibitor which increases erythropoietin production in end-stage kidney disease.
[Biochem/physiol Actions]

BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD). BIQ induces significant and reversible plasma erythropoietin (EPO) levels in vitro and in hemodialysis patients.
[References]

1. hsieh mm, linde ns, wynter a et al. hif prolyl hydroxylase inhibitionresults in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. blood. 2007 sep 15;110(6):2140-7.
Spectrum DetailBack Directory
[Spectrum Detail]

FG 2216(223387-75-5)1HNMR
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