| Identification | More | [Name]
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE | [CAS]
218457-67-1 | [Synonyms]
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE
BUTTPARK 96\12-100 | [Molecular Formula]
C15H18N2O | [MDL Number]
MFCD00052647 | [Molecular Weight]
242.32 | [MOL File]
218457-67-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
89-90 | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO (>30 mg/ml) | [form ]
solid | [color ]
Off-white to pale orange | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [CAS DataBase Reference]
218457-67-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors. | [References]
Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292 |
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