| Identification | Back Directory | [Name]
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate | [CAS]
206184-49-8 | [Synonyms]
Tenofovir(H2O)
Unii-99yxe507il
PMPA Monohydrate
Tenofovir (15 mg)
Tenofovir (hydrate)
R-PMPA of Tenofovir
Tenofovir Monohydrate
(R)-9-(2-phosphonylmethoxy propyl)adenine(R-PMPA)
9-[(R)-2-(Phosphonomethoxy)propyl]adenine 1-hydrate
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
[(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methylphosphonic acid
(R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid hydrate
(r)-[[2-(6-amino-9h-purin-9-yl)-1-methylethoxy]methyl]-phosphonic acid monohydrate
[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid monohydrate
Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, hydrate (1:1) | [EINECS(EC#)]
808-956-8 | [Molecular Formula]
C9H16N5O5P | [MDL Number]
MFCD11519982 | [MOL File]
206184-49-8.mol | [Molecular Weight]
305.23 |
| Chemical Properties | Back Directory | [Melting point ]
270-274oC | [storage temp. ]
2-8°C | [solubility ]
Aqueous Acid (Slightly), DMSO (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE POWDER SOLID | [Uses]
antineoplastic, thymidylate synthase inhibitor | [Definition]
ChEBI: A hydrate that is the monohydrate form of anhydrous tenovir. | [General Description]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Tenofovir is a nucleotide analog reverse transcriptase inhibitor, and is widely used as an antiretroviral agent, for the treatment of HIV infection. | [Biological Activity]
tenofovir hydrate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(hiv-1) and hepatitis b [1].tenofovir hydrate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. in addition, tenofovir hydrate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of hiv-1infection with ec50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. and the ec90 values of tenofovir hydrate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1]. | [storage]
Store at -20°C | [References]
[1] duwal s1, schütte c, von kleist m.pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against hiv-1 infection. plos one. 2012;7(7):e40382. doi: 10.1371/journal.pone.0040382. epub 2012 jul 11. |
|
|