| Identification | More | [Name]
5-Bromo-2-furaldehyde | [CAS]
1899-24-7 | [Synonyms]
5-BROMO-2-FURALDEHYDE
5-BROMO-2-FURFURAL
5-BROMOFURAN-2-CARBOXALDEHYDE
5-BROMOFURANCARBOXALDEHYDE
5-BROMOFURFURAL
5-Bromo-2-furaldehyde, 5-Bromo-2-furfural
5-BROMO-2-FURANALDEHYDE
5-Bromofuraldehyde
5-Bromo-2-furaldehyde, GC 99%
5-BROMO-2-FURALDEHYDE 97%
5-bromo-2-furaldehye
5-BROMO-FURAN-2-CARBALDEHYDE
5-Bromo-2-furaldehyde, 98+%
2-Bromo-5-furancarboxaldehyde
2-Bromofuran-5-carboxaldehyde
5-Bromo-2-formylfuran
5-Bromo-2-furancarbaldehyde
5-Bromo-2-furaldehyde, 98%, stab. with 2% ethanol | [EINECS(EC#)]
628-757-8 | [Molecular Formula]
C5H3BrO2 | [MDL Number]
MFCD00159501 | [Molecular Weight]
174.98 | [MOL File]
1899-24-7.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
82-85 °C (lit.) | [Boiling point ]
112 °C/16 mmHg (lit.) | [density ]
1.5940 (rough estimate) | [refractive index ]
1.4450 (estimate) | [Fp ]
112°C/6mm | [storage temp. ]
Refrigerator | [solubility ]
Chloroform, Methanol | [form ]
Powder | [color ]
Slightly yellow | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Sensitive ]
Air Sensitive | [BRN ]
108403 | [CAS DataBase Reference]
1899-24-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Harmful | [HazardClass ]
IRRITANT | [HS Code ]
29130000 |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Physical properties]
5-Bromo-2-furfuraldehyde is a light yellow powder, soluble in carbon dichloride , carbon tetrachloride, ether and other organic solvents. | [Uses]
5-Bromo-2-furaldehyde is used in the preparation of isoindolinones from furfural. Also used in the preparation of brominated nitrovinylfuran which displays antibacterial activity.
| [Preparation]
A three-necked 50 mL round bottom flask was charged with [bmim]Br3 (20 mmol) followed by dropwise addition of freshly distilled 2-furfural (20 mmol) over a period of 0.5 h and the reaction mixture was stirred for at 40 ℃ 2.5 h under nitrogen atmosphere. The mixture was extracted with petroleum ether (30 mL × 3), the organic layer was washed with water, dried (sodium sulfate) and concentrated. The crude product was purified by distillation and recrystallization with 10 % ethyl acetate-ether solution.
5-Bromo-2-furfural of yellowish crystal in 88 % yield was obtained. Mp. 82-85 ℃, 1H NMR (CDCl3), δ: 9.55 (s, 1H), 7.25 (s, 1H), 6.57 (s, 1H).
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