| Identification | Back Directory | [Name]
2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid | [CAS]
188968-51-6 | [Synonyms]
D03497
CS-1500
CS-2674
EMD 12197
EMD-85189
NSC 707544
Cilengitide
C(RGDf-Me-V)
c(RGDf(NMe)V)
Cilengitide, >=98%
cilengitide USP/EP/BP
Cilengitide (EMD 121974)
EMD 121974;EMD-121974;EMD121974
Cyclo(Arg-Gly-Asp-D-Phe-N-Me-Val)
Cilengitide(EMD121974,NSC-707544)
EMD 12197;EMD-85189;EMD-121974;NSC-707544;D03497
Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
2-((2S,5R,8S,11S)-5-Benzyl-11-(3-guanidinopropyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1
2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]aceticaci
2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid | [Molecular Formula]
C27H40N8O7 | [MDL Number]
MFCD04307743 | [MOL File]
188968-51-6.mol | [Molecular Weight]
588.662 |
| Chemical Properties | Back Directory | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
≥29.43 mg/mL in DMSO; ≥22.56 mg/mL in H2O | [form ]
powder | [pka]
4.01±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
Soluble to 10 mg/ml in water | [InChIKey]
AMLYAMJWYAIXIA-MAVOJUFWNA-N | [SMILES]
N1(C)[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC2C=CC=CC=2)C1=O |&1:2,9,24,32,r| |
| Hazard Information | Back Directory | [Uses]
Angiogenesis
inhibitor. | [Definition]
ChEBI: Cilengitide is an oligopeptide. | [Biochem/physiol Actions]
It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of α and β chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration. | [storage]
Store at -20°C |
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