| Identification | Back Directory | [Name]
LY 294002 HYDROCHLORIDE | [CAS]
154447-36-6 | [Synonyms]
SF 1101
LY 294002
NSC 697286
LY294002HCl
LY 294002, 99+%
LY294002 (HCI Salt)
LY 294002 HYDROCHLORIDE
2-Morpholino-8-phenylchroMone
2-Morpholino-8-phenyl-4H-chroMen-4-one
8-Phenyl-2-(morpholin-4-yl)chromen-4-one
2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
2-[4-Morpholinyl]-8-phenyl-1[4H]-benzopyran-4-on
2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE
LY 294002
8-Phenyl-2-(morpholin-4-yl)chromen-4-one
2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE
2-(4-morpholinyl)-8-phenyl-1(4h)-benzopyran-4-one hydrochloride
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one LY 294002 | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C19H18ClNO3 | [MDL Number]
MFCD01530034 | [MOL File]
154447-36-6.mol | [Molecular Weight]
343.8 |
| Chemical Properties | Back Directory | [Melting point ]
183-185℃ | [Boiling point ]
494.6±45.0 °C(Predicted) | [density ]
1.266 | [storage temp. ]
2-8°C
| [solubility ]
DMSO: >5 mg/mL
| [form ]
solid
| [pka]
0.55±0.20(Predicted) | [color ]
white to off-white
| [Water Solubility ]
Soluble in DMSO at 5mg/ml. Insoluble in water | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. | [InChIKey]
CZQHHVNHHHRRDU-UHFFFAOYSA-N | [CAS DataBase Reference]
154447-36-6 |
| Hazard Information | Back Directory | [Biological Activity]
A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo . | [Description]
LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.1 | [Uses]
A potent blocker of PI 3-kinase/Akt signaling. | [Uses]
LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice. | [Uses]
LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM. | [Definition]
ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. | [target]
p110α | [storage]
Store at -20°C | [References]
1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241 |
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