| Identification | More | [Name]
N-Succinimidyl-N-methylcarbamate | [CAS]
18342-66-0 | [Synonyms]
2,5-PYRROLIDINEDIONE, 1-[[(METHYLAMINO)CARBONYL]OXY]-
N-SUCCINIMDYL-N-METHYLCARBAMATE
N-SUCCINIMIDYL-N-METHYLCARBAMATE
N-Succinimidyl-N-methylcarbama
methyl isocyanate substitute
Methyl isocyanate substitute, MIC substitute | [Molecular Formula]
C6H7N2O4- | [MDL Number]
MFCD00800292 | [Molecular Weight]
171.13 | [MOL File]
18342-66-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
148-153 °C | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
Dichloromethane (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
11.00±0.46(Predicted) | [color ]
White to Off-White | [Water Solubility ]
Slightly soluble in water. | [Sensitive ]
Moisture Sensitive | [BRN ]
1531863 | [CAS DataBase Reference]
18342-66-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10-21 | [HS Code ]
2928.00.5000 |
| Hazard Information | Back Directory | [Uses]
N-Succinimidyl N-Methylcarbamate is used as a reagent in the synthesis of Argifin, a natural product chitinase inhibitor with chemotherapeutic potential. N-Succinimidyl N-Methylcarbamate is also used as a reagent in the preparation of 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide (A616300); a metabolite of Temozolomide (T017775) which is an imidazotetrazine alkylating agent and antineoplastic. | [Definition]
ChEBI: N-succinimidyl N-methylcarbamate is a member of the class of pyrrolidinones that is N-hydroxysuccinimide in which the hydroxyl hydrogen is replaced by a methylcarbamoyl group. It has a role as an apoptosis inducer. It is a carbamate ester, a dicarboximide, a pyrrolidinone and a N-hydroxysuccinimide ester. It is functionally related to a succinimide. |
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