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ChemicalBook--->CAS DataBase List--->183322-45-4

183322-45-4

183322-45-4 Structure

183322-45-4 Structure
IdentificationBack Directory
[Name]

PD153035 HCl
[CAS]

183322-45-4
[Synonyms]

CS-473
ZM 252868
ZM 252868 HCl
AG 1517, SU 5271
PD153035 (HCl salt)
PD153035 HCl (SU5271
AG1517 (Hydrochloride)
PD153035 HCl USP/EP/BP
SU-5271 (Hydrochloride)
ZM 252868 (Hydrochloride)
PD 153035 Hydrochloride >
PD153035 HCl (SU-5271, AG1517)
PD 153035 hydrochloride, >=98%
PD153035 Hydrochloride PD-153035
PD153035 Hydrochloride (ZM 252868
9-DIAMINO-2-ETHOXYACRIDINE LACTATE
SU-5271 (AG1517) HCl ,ZM 252868 HCl
PD 153035 Isethionate Salt DISCONTINUED
PD 153035;SU 5271; AG-1517;PD-153035;SU5271; AG 1517
N-(3-BroMophenyl)-6,7-diMethoxyquinazolin-4-aMine hydrochloride
N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine Hydrochloride
6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride
4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, monohydrochloride
PD 153035;SU 5271; AG-1517;PD-153035;SU5271; AG 1517;ZM 252868; TYRPHOSTIN AG 1517
6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride PD153035
[Molecular Formula]

C16H14BrN3O2.HCl
[MDL Number]

MFCD01074805
[MOL File]

183322-45-4.mol
Chemical PropertiesBack Directory
[Melting point ]

265°C(lit.)
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble2mg/mL, clear (warmed)
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

25-37/38-41
[Safety Statements ]

26-39-45
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
[HS Code ]

2933.59.8000
Hazard InformationBack Directory
[Uses]

PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM).
[Definition]

ChEBI: A hydrochloride obtained by combining PD-153035 with one equivalent of hydrochloric acid.
[Enzyme inhibitor]

This extraordinarily potent EGFR inhibitor (F.Wt. = 396.67 (as hydrochloride); CAS 183322-45-4 (hydrochloride), 153436-54-5 (free base); Solubility (25°C) : <1 mg/mL DMSO, <1 mg/mL Water), also known systematically as N- (3-bromophenyl) -6,7-dimethoxyquinazolin-4-amine, rapidly suppresses in vitro EGFR autophosphorylation (Ki = 5.2 pM; IC50 = 29 pM) and selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. PD153035 exposure does not affect the expression of either EGF receptors or HER2/neu. PD153035 causes dose-dependent growth inhibition of EGF receptor-overexpressing cell lines at low micromolar concentrations, and the IC50 values in monolayer cultures at less than 1 μM in most cell lines tested.
Spectrum DetailBack Directory
[Spectrum Detail]

PD153035 HCl(183322-45-4)1HNMR
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