| Identification | Back Directory | [Name]
Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-L-phenylalanyl- | [CAS]
1817857-75-2 | [Synonyms]
Fmoc-GGFG
Fmoc-GGFG-OH
(((9H-Fluoren-9-yl)methoxy)carbonyl)glycylglycyl-L-phenylalanylglycine
Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-L-phenylalanyl- | [Molecular Formula]
C30H30N4O7 | [MOL File]
1817857-75-2.mol | [Molecular Weight]
558.58 |
| Chemical Properties | Back Directory | [Boiling point ]
980.0±65.0 °C(Predicted) | [density ]
1.329±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.32±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
LCOCGQVZUSLQJD-VWLOTQADSA-N | [SMILES]
C(O)(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
| Hazard Information | Back Directory | [Uses]
Fomc-Gly-Gly-Phe-Gly-OH, also known as FMOC-GGFG-OH or 2-[[(2S)-2-[[2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid, can be used as an intermediate in the synthesis of ADC dual-drug-linker. Fomc-Gly-Gly-Phe-Gly-OH synthetic intermediate GGFGE further forms an important ADC dual-drug link assembly unit | [Definition]
Fomc-gly-gly-ph-gly-OH contains several functional groups. The Fmoc group is a commonly used protective group in peptide synthesis and is often used to protect N-terminal amino groups. Gly-Gly-Phe-Gly is glycyl-glycyl-phenylalanyl-glycine (GGFG) peptide which can be linked to other groups (drug) through cysteine residues. This tetrapeptide linker is protease-cleavable.
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