| Identification | Back Directory | [Name]
Fmoc-Val-ala-PAB | [CAS]
1394238-91-5 | [Synonyms]
CS-2746
Fmoc-Val-ala-PAB
Fmoc-Val-Ala-PAB-OH
Fmoc-Val-Ala-PAB-OH, 9-fluorenylmethyloxycarbonyl-valyl-alanyl-4-aminobenzylalcohol
L-Alaninamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-
(9H-Fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate | [Molecular Formula]
C30H33N3O5 | [MDL Number]
MFCD28557282 | [MOL File]
1394238-91-5.mol | [Molecular Weight]
515.6 |
| Chemical Properties | Back Directory | [Melting point ]
218 °C(dec.) | [Boiling point ]
811.1±65.0 °C(Predicted) | [density ]
1.251±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 33.33 mg/mL (64.64 mM; ultrasonic and warming and heat to 80°C) | [form ]
powder to crystal | [pka]
10.63±0.46(Predicted) | [color ]
White to Light yellow |
| Hazard Information | Back Directory | [Description]
Fmoc-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. | [Uses]
Fmoc-Val-Ala-PAB is a building block used in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers. | [IC 50]
Protease Cleavable Linker; Cleavable Linker |
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