| Identification | Back Directory | [Name]
DBeQ | [CAS]
177355-84-9 | [Synonyms]
JRF
DBeQ
JRF 12
CS-982
DBeQ (JRF 12)
DBeQ USP/EP/BP
JRF 12; JRF12; JRF-12
N,N'-Dibenzylquinazoline-2,4-diamine
N2,N4-Dibenzylquinazoline-2,4-diamine
N,N'-Dibenzyl-2,4-quinazolinediamine, 99%
N,N'-Dibenzylquinazoline-2,4-diamine DBeQ
N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
2,4-QuinazolinediaMine, N,N'-bis(phenylMethyl)-
2,4-QuinazolinediaMine, N2,N4-bis(phenylMethyl)-
N2,N4-Dibenzylquinazoline-2,4-diamine
DBeQ | [Molecular Formula]
C22H20N4 | [MDL Number]
MFCD03691820 | [MOL File]
177355-84-9.mol | [Molecular Weight]
340.421 |
| Chemical Properties | Back Directory | [Melting point ]
149 °C | [Boiling point ]
573.1±52.0 °C(Predicted) | [density ]
1.259±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [pka]
7.78±0.30(Predicted) | [color ]
white to beige | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. | [InChIKey]
QAIMUUJJAJBPCL-UHFFFAOYSA-N | [CAS DataBase Reference]
177355-84-9 |
| Hazard Information | Back Directory | [Description]
DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell permeable. | [Uses]
The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical] | [Biochem/physiol Actions]
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis. | [storage]
Store at -20°C | [References]
1) Chou et al. (2011), Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proc. Natl. Acad. Sci. USA, 108 4834 |
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