| Identification | Back Directory | [Name]
Afatinib iMpurity | [CAS]
1680184-59-1 | [Synonyms]
Cis-Afatinib
(2Z)-Afatinib
Afatinib iMpurity
Afatinib (Z)-Isomer
Afatinib Impurity B (2Z)-Afatinib
Afatinib Impurity 18（(2Z) Afatinib）
1-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2Z)- | [Molecular Formula]
C24H25ClFN5O3 | [MOL File]
1680184-59-1.mol | [Molecular Weight]
485.94 |
| Chemical Properties | Back Directory | [Melting point ]
>134°C (dec.) | [Boiling point ]
676.9±55.0 °C(Predicted) | [density ]
1.380±0.06 g/cm3(Predicted) | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
11.79±0.43(Predicted) | [color ]
Pale Yellow to Light Yellow | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
(2Z)-Afatinib is a structural analogue of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. |
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