Identification | Back Directory | [Name]
CIS-HEXAHYDROISOINDOLINE HYDROGEN CHLORIDE | [CAS]
161829-92-1 | [Synonyms]
Cis-hexahydroisoindolineHCL Cis-hexahydroisoindole, HCl cis-Octahydroisoindole hydrochloride Cis-Hexahydroisoindoline hydrochloride CIS-HEXAHYDROISOINDOLINE HYDROGEN CHLORIDE (3aR,7aS)-octahydro-1H-isoindole hydrochloride (3aR,7aS)-rel-Octahydro-1H-isoindole hydrochloride rel-(3aR,7aS)-Octahydro-1H-isoindole hydrochloride (3aR,7aS)-octahydro-1H-isoindole hydrochloride (1:1) (3aR,7aS)-rel-octahydro-1H-Isoindole, hydrochloride (1:1) 1H-Isoindole,octahydro-, hydrochloride, (3aR,7aS)-rel- (9CI) (3aR,7aS)-2,3,3a,4,5,6,7,7a-Octahydro-1H-isoindole hydrochloride 5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C8H16ClN | [MDL Number]
MFCD09026400 | [MOL File]
161829-92-1.mol | [Molecular Weight]
161.672 |
Chemical Properties | Back Directory | [Melting point ]
121-123 °C | [storage temp. ]
Sealed in dry,Room Temperature | [InChI]
InChI=1/C8H15N.ClH/c1-2-4-8-6-9-5-7(8)3-1;/h7-9H,1-6H2;1H/t7-,8+; | [InChIKey]
CLQIZUYXKFTUEB-KVZVIFLMNA-N | [SMILES]
[H][C@]12CCCC[C@@]1([H])CNC2.Cl |&1:1,6,r| |
Hazard Information | Back Directory | [Description]
Cis-Octahydro-1H-isoindole hydrochloride is an important intermediate in the synthesis of mitiglinide which is a new oral hypoglycemic drug for the treatment of type II diabetes for the first marked in Japan
| [Preparation]
Phthalimide was used as raw material to react with KOH. Benzyl bromide was subsequently added to the solution to obtain the N-benzylphthalimide. The addition of lithium tetrahydroaluminum, reducing compound N-benzylphthalimide, yields N-benzyldihydroisoindole. Finally, cis-Octahydro-1H-isoindole hydrochlorid is obtained by Pd/C catalysis and reduction |
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