| Identification | Back Directory | [Name]
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM | [CAS]
148892-91-5 | [Synonyms]
UQABYHGXWYXDTK-QXQKWMGSSA-N
Guanosine 5′-[β,γ-imido]triphosphate
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
Guanylyl Imidodiphosphate Trisodium Salt
β:γ-imidoguanosine 5'-triphosphate trisodium salt
guanosine 5'-[β,γ-imido]triphosphate trisodium salt
5′-Guanylyl-imidodiphosphate trisodium salt hydrate
β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate
Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate
Guanosine 5μ-[β,γ-imido]triphosphate hydrate trisodium salt
Guanosine 5'-[beta,gamma-imido]triphosphate trisodium salt hydrate
5μ-Guanylyl-imidodiphosphate hydrate trisodium salt, GMP-PNP, Gpp(NH)p, β:γ-Imidoguanosine 5μ-triphosphate hydrate trisodium salt | [Molecular Formula]
C10H13N6Na3O10P2 | [MDL Number]
MFCD00084770 | [MOL File]
148892-91-5.mol | [Molecular Weight]
508.161 |
| Hazard Information | Back Directory | [Uses]
Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex. | [Uses]
Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor. | [General Description]
Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes. | [Biochem/physiol Actions]
Guanosine 5′-[?,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis. |
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