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ChemicalBook--->CAS DataBase List--->461681-88-9

461681-88-9

461681-88-9 Structure

461681-88-9 Structure
IdentificationBack Directory
[Name]

EXO1
[CAS]

461681-88-9
[Synonyms]

EXO1
EOX 1
hExo1
hExoI
Exonuclease 1
EXOCYTIC INHIBITOR 1
4-FLUORO-BZ-2-ABZ-OME
2-(4-FLUOROBENZOYLAMINO)METHYLBENZOATE
Anti-EXO1, N-Terminal antibody produced in rabbit
2-(4-FLUOROBENZOYLAMINO)BENZOIC ACID METHYL ESTER
Methyl 3-(4-fluorobenzoyl)-6-methyl-2-pyridinecarboxylate
[Molecular Formula]

C15H12FNO3
[MDL Number]

MFCD00028104
[MOL File]

461681-88-9.mol
[Molecular Weight]

273.26
Chemical PropertiesBack Directory
[Melting point ]

132-134℃
[storage temp. ]

Store at RT
[solubility ]

DMSO: 19 mg/mL, soluble
[form ]

solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H312-H332
[Precautionary statements ]

P261-P280h-P301+P312a-P304+P340-P321-P501a
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Exo1 is used in the synthetic preparation of tricyclic heterocyclic compounds as antagonists of tachykinin receptor (substance P receptor) for prevention and/or treatment of substance P-related diseases.
[Definition]

ChEBI: 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester is a member of benzamides.
[Biological Activity]

Reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC 50 ~ 20 mM). Has similar, but not identical, action to brefeldin A (1,6,7,8,9,11ab,12,13,14,14aa-Decahydro-1b,13a-dihydroxy-6b-methyl-4H-cyclopent(f)oxacyclotridecin-4-one ).
Spectrum DetailBack Directory
[Spectrum Detail]

EXO1(461681-88-9)1HNMR
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