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ChemicalBook--->CAS DataBase List--->147497-32-3

147497-32-3

147497-32-3 Structure

147497-32-3 Structure
IdentificationBack Directory
[Name]

6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
[CAS]

147497-32-3
[Synonyms]

6-BROMO-3,4-1(1H)-ISOQUINOLINONE
6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ON
6-Bromo-3,4-dihydro-1(2H)-isoquinolinone
6-BROMO-3,4-DIHYDRO-1(1H)-ISOQUINOLINONE
6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
6-bromo-3,4-dihydroisoquinolin-1(2H)-one
1(2H)-Isoquinolinone, 6-bromo-3,4-dihydro-
6-broMo-1,2,3,4-tetrahydroisoquinolin-1-one
6-BroMo-1-oxo-1,2,3,4-tetrahydroisoquinoline
[Molecular Formula]

C9H8BrNO
[MDL Number]

MFCD04114858
[MOL File]

147497-32-3.mol
[Molecular Weight]

226.07
Chemical PropertiesBack Directory
[Melting point ]

170.0-173.1 °C
[Boiling point ]

453.3±45.0 °C(Predicted)
[density ]

1.559±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[pka]

14.22±0.20(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Methanol-->Diethyl ether-->Sulfuric acid-->Tetrahydrofuran-->Dichloromethane-->Sodium sulfate-->Magnesium sulfate-->Triethylamine-->Sodium chloride-->Sodium bicarbonate-->Lithium Aluminum Hydride-->Polyphosphoric acid-->Ethyl chloroformate-->3-Bromophenylacetonitrile-->[2-(4-Bromo-phenyl)-ethyl]-carbamic acid methyl ester
Hazard InformationBack Directory
[Uses]

6-bromo-3,4-dihydroisoquinolin-1(2H)-one is an intermediate used in the synthesis of benzolactams as dopamine D3 receptor ligands.IT is also used in the synthesis of new, selective 3-aminopyrazole based MK2-inhibitors that was proved to inhibit intracellular phosphorylation of hsp27 as well as LPS-induced TNFα release in cells.
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