| Identification | More | [Name]
4-tert-Octylphenol | [CAS]
140-66-9 | [Synonyms]
4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL
4-(DI-ISO-BUTYL) PHENOL
4-TERT-OCTYLPHENOL
OCTYLPHENOL
P-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL
P-(1,1,3,3-TETRAMETHYL-N-BUTYL)PHENOL
PARA-TERT-OCTYLPHENOL
P-TERT-OCTYLPHENOL
P-T-OCTYL PHENOL
PTOP
TIMTEC-BB SBB008090
-(1,1,3,3-tetramethylbutyl)phenol
4-(1,1,3,3-tetramethylbutyl)-pheno
p-(1,1,3,3-tetramethylbutyl)-pheno
p-(1’,1’,3’,3’-tetramethylbutyl)fenol
p-(tert-octyl)-pheno
Phenol, p-(1,1,3,3-tetramethylbutyl)-
Phenol, p-(tert-octyl)-
phenol,-(1,1,3,3-tetramethylbutyl)-
p-octylphenol | [EINECS(EC#)]
205-426-2 | [Molecular Formula]
C14H22O | [MDL Number]
MFCD00002368 | [Molecular Weight]
206.32 | [MOL File]
140-66-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
79-82 °C(lit.)
| [Boiling point ]
175 °C30 mm Hg(lit.)
| [density ]
0.95 g/cm3 (20℃) | [vapor pressure ]
2Pa at 38℃ | [refractive index ]
1.5003 (estimate) | [Fp ]
145 °C | [storage temp. ]
-20°C | [solubility ]
water: slightly soluble0.007g/L at 20°C | [form ]
neat | [pka]
10.15±0.15(Predicted) | [color ]
White flakes | [PH Range]
6 at 10 g/l at 20 °C | [Stability:]
Stable. Incompatible with strong oxidizing agents, strong bases. | [Water Solubility ]
7mg/L at 20℃ | [BRN ]
513992 | [LogP]
4.8 at 22℃ | [CAS DataBase Reference]
140-66-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Phenol, 4-(1,1,3,3-tetramethylbutyl)-(140-66-9) | [EPA Substance Registry System]
140-66-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R21:Harmful in contact with skin.
R38:Irritating to the skin.
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
2430 | [WGK Germany ]
2
| [RTECS ]
SM9625000
| [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29071300 | [Hazardous Substances Data]
140-66-9(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
4-tert-Octylphenol (4t-OP) is used in manufacturing processes
as an intermediate in the generation of surfactants, synthetic
rubber additives, or resins. 4t-OP is also used to manufacture
alkylphenol ethoxylates. It is found mainly in detergents,
cleaning products, and emulsifiers and less frequently in paints,
personal care products, pesticides, paper, pulp, and textiles.
There is a paucity of data on food levels of 4t-OP, with
one study reporting 19 ng g-1 wet weight 4t-OP in baby food
and similar concentrations reported in seafood. Urinary 4t-OP
reflects recent exposure; the 95th percentile (confidence
interval) urine concentration of 4t-OP in the US population as
reported by the US Centers for Disease Control in the National
Health and Nutrition Examination Survey is 2.2 (1.6–3.2)
mg l-1. | [Uses]
A common environmental pollutant showing weak estrogenic effects. 4-tert-Octylphenol has been shown to cause harm to the male reproductive system of vertebrates.
| [Uses]
Surfactants, Tackifier Resins, Ink Resins, Polycarbonate Chain Terminator, Ultraviolet Stabilizers | [Definition]
ChEBI: 4-tert-Octylphenol is an alkylbenzene. | [General Description]
4-tert-Octylphenol is a potential environmental pollutant and it exhibits toxic and estrogenic effects on mammalian cells. It binds to estrogen receptors and exerts estrogenic actions in vitro. The transformation of the 4-tert-octylphenol upon irradiation at 253.7nm and by hydroxyl radicals generated by the photolysis (λexc = 253.7nm) of hydrogen peroxide in aqueous solution has been studied. | [Health effects]
4-tert-octylphenol can affect the reproductive system of animals and affect how babies develop. It can also affect how hormones are produced in animals.
High doses of several alkylphenols, including 4- tert-octylphenol, have altered estrogenic effects, including sex hormone levels, estrus cycles, reproductive outcomes, neonatal sexual development, as well as impaired production of steroid hormone and testicular atrophy. | [Environmental Fate]
Studies have shown that 4t-OP will adsorb to sediments. | [Purification Methods]
Crystallise the phenol from n-hexane and/or distil it in a vacuum. [Beilstein 6 III 2051, 6 IV 3484.] | [Toxicity evaluation]
4t-OP has been shown to be an estrogen receptor (ER) agonist.
Estrogenic effects of 4t-OP have been demonstrated in human
cells, with 4t-OP displacing the natural estrogen 17b estradiol
from its receptor, and 4t-OP inducing cell proliferation in
estrogen-dependent cell proliferation assays. In vivo confirmation
of 4t-OP’s estrogenicity has been confirmed with the uterotrophic
assay. |
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