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ChemicalBook--->CAS DataBase List--->1393330-33-0

1393330-33-0

1393330-33-0 Structure

1393330-33-0 Structure
IdentificationBack Directory
[Name]

Bromo-PEG1-Acid
[CAS]

1393330-33-0
[Synonyms]

Bromo-PEG1-Acid
CAS_1393330-33-0
Br-PEG1-CH2CH2COOH
Bromo-PEG1-acid >=95%
Bromo-PEG1-propionic acid
3-(2-Bromoethoxy)propanoic acid
Propanoic acid, 3-(2-bromoethoxy)-
[Molecular Formula]

C5H9BrO3
[MDL Number]

MFCD22574802
[MOL File]

1393330-33-0.mol
[Molecular Weight]

197.03
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[solubility ]

DMSO : 100 mg/mL (507.54 mM; Need ultrasonic)
[form ]

Liquid
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[HS Code ]

2918999090
Hazard InformationBack Directory
[Description]

Bromo-PEG1-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
[Uses]

Bromo-PEG1-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG1-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
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