| Identification | Back Directory | [Name]
Bromo-PEG2-t-butyl ester | [CAS]
1381861-91-1 | [Synonyms]
1381861-91-1
Br-PEG2-COOtBu
CAS_1381861-91-1
Bromo-PEG2-C2-Boc
Br-PEG2-CH2CH2COOtBu
Br-PEG2-t-butyl ester
Bromo-PEG2-t-butyl ester
Bromo-PEG3-t-butyl ester
tert-Butyl 3-(2-(2-bromoethoxy)ethoxy)propanoate
Propanoic acid, 3-[2-(2-bromoethoxy)ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C11H21BrO4 | [MDL Number]
MFCD22574822 | [MOL File]
1381861-91-1.mol | [Molecular Weight]
297.19 |
| Chemical Properties | Back Directory | [Boiling point ]
332.0±22.0 °C(Predicted) | [density ]
1.240±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bromo-PEG2-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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