| Identification | Back Directory | [Name]
Tropifexor | [CAS]
1383816-29-2 | [Synonyms]
LJN452
CS-2712
CPD1549
Tropifexor
LJN452;CPD1549
LJN452,Tropifexor
Tropifexor (LJN452)
LJN 452;LJN-452;LJN452
6-Benzothiazolecarboxylic acid, 2-[(3-endo)-3-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl]methoxy]-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro-
rel-2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid
2-rel-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid
2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid | [Molecular Formula]
C29H25F4N3O5S | [MDL Number]
MFCD31619256 | [MOL File]
1383816-29-2.mol | [Molecular Weight]
603.58 |
| Chemical Properties | Back Directory | [Boiling point ]
700.0±65.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:80.66(Max Conc. mg/mL);133.64(Max Conc. mM) | [form ]
A crystalline solid | [pka]
3.84±0.10(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
Tropifexor, is a highly potent non-bile acid FXR agonist for the treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH). |
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