| Identification | Back Directory | [Name]
Abacavir 5’-Phosphate | [CAS]
136470-77-4 | [Synonyms]
Abacavir Impurity 13
Abacavir 5’-Phosphate
(1S-cis)-Abacavir Monophosphate
[(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methyl dihydrogen phosphate
((1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enyl)methyl dihydrogen phosphate
2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, 1-(dihydrogen phosphate), (1S,4R)-
(1S,4R)- 4-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]-2-cyclopentene-1-Methanol
Dihydrogen Phosphate (Ester) | [Molecular Formula]
C14H19N6O4P | [MDL Number]
MFCD23160255 | [MOL File]
136470-77-4.mol | [Molecular Weight]
366.31 |
| Chemical Properties | Back Directory | [Melting point ]
189-194°C (dec.) | [Boiling point ]
749.3±70.0 °C(Predicted) | [density ]
1.93±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Methanol, Water | [form ]
Solid | [pka]
1.91±0.10(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A metabolite of Abacavir (A105000). | [Uses]
Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. | [Definition]
ChEBI: Abacavir monophosphate is the organic phosphate that is the 5'-monophosphate of abacavir. It has a role as a metabolite. It is a member of 2,6-diaminopurines and an organic phosphate. It is functionally related to an abacavir. |
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