| Identification | Back Directory | [Name]
6-aminocarbovir | [CAS]
124752-25-6 | [Synonyms]
6-aminocarbovir
Abacavir Impurity C
Descyclopropyl Abacavir
Abacavir amine impurity
(Abacavir EP Impurity C)
Abacavir Related CoMpound A
Abacavir Sulfate Impurity C
Descyclopropyl Abacavir (USP)
Abacavir Sulfate EP Impurity C
Abacavir USP Related Compound A
Abacavir Sulfate - Impurity C (Freebase)
Abacavir Impurity 3(Abacavir EP Impurity C)
(1α,4α)-4-(2,6-Diamino-9H-purin-9-yl)-2-cyclopentenyl-carbinol
(1S,4R)-4-(2,6-DiaMino-9H-purin-9-yl)-2-cyclopentene-1-Methanol
[(1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)cyclopent-2-enyl]methanol
2-Cyclopentene-1-methanol, 4-(2,6-diamino-9H-purin-9-yl)-, (1S,4R)-
[(1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)cyclopent-2-en-1- yl]methanol
2-Cyclopentene-1-methanol, 4-(2,6-diamino-9H-purin-9-yl)-, (1S-cis)-
(-)-2,6-Diamino-9-[(1R)-4β-(hydroxymethyl)-2-cyclopentene-1β-yl]-6,9-dihydro-1H-purine
Abacavir Related Compound A (20 mg) ([4-(2,6-diamino-9H-purin-9-yl)cyclopent-2-enyl]methanol)
Abacavir Related Compound A ([4-(2,6-diamino-9H-purin-9-yl)cyclopent-2-enyl]methanol) (1000420) | [Molecular Formula]
C11H14N6O | [MDL Number]
MFCD00869644 | [MOL File]
124752-25-6.mol | [Molecular Weight]
246.27 |
| Chemical Properties | Back Directory | [Melting point ]
180-182°C | [Boiling point ]
628.2±65.0 °C(Predicted) | [density ]
1.75±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
neat | [pka]
14.86±0.10(Predicted) | [color ]
Off-White to Pale Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Yellow Solid | [Uses]
Abacavir Intermediate. | [Uses]
Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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