| Identification | More | [Name]
Quinalphos | [CAS]
13593-03-8 | [Synonyms]
Bayrusil
Bayrusil granules
BAYRUSIL(R)
DANULUX
diethyl o-(2-quinoxalyl) phosphorothioate
EKALUX
Ekalux granules
EKALUX(R)
GUINALPHOS
HUBELUX
KINALUX(R)
KRUSH
O,O-DIETHYL O-2-QUINOXALINYL PHOSPHOROTHIOATE
O,O-DIETHYL-O-QUINOXALIN-2-YL-PHOSPHOROTHIOATE
QUINAAL
QUINALPHOS
Quinalphos granules
QUINATOX
QUINATOX(R)
SMASH | [EINECS(EC#)]
237-031-6 | [Molecular Formula]
C12H15N2O3PS | [MDL Number]
MFCD00078719 | [Molecular Weight]
298.3 | [MOL File]
13593-03-8.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T,N,Xn,F | [Risk Statements ]
R21:Harmful in contact with skin.
R25:Toxic if swallowed.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36:Irritating to the eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
2783 | [WGK Germany ]
3 | [RTECS ]
TF6125000 | [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
29339900 | [Safety Profile]
Poison by ingestion,
inhalation, skin contact, parenteral, and
intraperitoneal routes. Experimental
reproductive effects. Mutation data
reported. An insecticide. When heated to decomposition it emits very toxic fumes of
NOx, POx, and SOx
| [Toxicity]
cat,LD50,oral,75mg/kg (75mg/kg),National Technical Information Service. Vol. OTS0555485, |
| Hazard Information | Back Directory | [Uses]
Quinalphos is used to control both chewing and sucking insects
and mites in a large number of different crops. | [Definition]
ChEBI: Quinalphos is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide and an agrochemical. It is functionally related to a quinoxalin-2-ol. | [Metabolic pathway]
In methanol solution, quinalphos undergoes
photodegradation reactions of isomerization, oxidation,
and deesterification, together with other degradation
reactions, resulting in several degradation products.
However, the photolysis of quinalphos in ethanol
solution yields the two products, O,O-diethyl-O-(3-
ethoxyquinoxalin-2-yl)phosphorothioate and O,O-
diethyl-O-[3(1-hydroxyethyl)-quinoxalin-
2yl]phosphorothioate, both of which are derived from
the reaction of the photoexcited quinalphos molecule
with the solvent. | [Degradation]
Quinalphos is susceptible to hydrolysis. The DT50 values at pH 3,6 and 9
were 23,39 and 26 days, respectively (PM). Quinalphos is very susceptible
to acid hydrolysis but stable under mildly basic conditions, having a halflife
ten times that of parathion at pH 11 (Schmidt, 1972). Quinalphos was
degraded in distilled water (pH 6.0), rain water (pH 6.8) and tap water
(pH 7.8) with DT50 values of 80,50 and 60 days, respectively (Dureja ef aI.,
1988). The photolysis of quinalphos in ethanolic solution irradiated by a
medium pressure mercury vapour lamp (λmax 366 nm) with a glass filter to
screen out light of <290 nm gave photoproducts principally derived from
reaction with the solvent. The main photolysis products were 3-ethoxyand
3-hydroxyethyl-quinoxaline derivatives of quinalphos (not shown in
Scheme 1). A minor product of photodegradation was quinalphos oxon
(2) (Pusino et al., 1989). When quinalphos was irradiated with a high
pressure mercury vapour lamp (λmax 254 nm) in a quartz reactor many
more photoproducts were detected, although whether this information is
relevant to photodegradation in the environment is debatable since light
of wavelength ﹤290 nm is generally absent at the Earth's surface. Using
this method of irradiation, Dureja et al. (1988) examined the photolysis of
quinalphos in hexane and methanol solution, as a thin film on a glass
plate and on the soil surface. Analysis of the photoproducts was by MS
and 1H NMR spectroscopy after separation by TLC and GC. The rates of
photodecomposition in aqueous solution and on soil surfaces exposed to
sunlight were also measured, although in these experiments the nature of
the photoproducts were not determined. In methanol solution, three
major pathways of photolysis were apparent: (a) de-esterification to
afford quinoxolin-2-o1(3), (b) thionethiolo rearangement to O,O-diethyl
S-quinoxalin-2-yl phosphorothioate (4), which was not actually detected
and was presumably de-esterified to give quinoxoline-2-thiol (5) which
dimerised to the disulfide (6) and the sulfide (7), and (c) oxidation of
the P=S sulfur to afford the oxon (2) as shown in Scheme 1. In addition,
the de-esterification of the phosphorothioate moiety and additional alkyl
transfer from quinalphos gave triethyl phosphate (S), O,O,O-triethyl
phosphorothioate (9) and O,O,S-triethyl phosphorodithioate (10). A
number of other photoproducts were identified which were formed via reaction of the methanol solvent with quinalphos (1) and quinoxolin-2-o1
(3) but because of their non-relevance to photoproducts produced under
environmental conditions they are not included in Scheme 1.
Irradiation of quinalphos as a thin film on glass produced quinalphos
oxon (2) and quinoxolin-2-o1(3) as the main photoproducts. The products
from the soil irradiation experiments were identified as quinalphos oxon
(2), the rearranged product O,O-diethyl S-quinoxalin-2-yl phosphorothioate
(4), quinoxolin-2-o1(3), quinoxoline-2-thiol(5) and the sulfide (7).
Routes for photodegradation of quinalphos in methanol solution, as a thin
film and on soil surfaces are shown in Scheme 1. Half-lives for the photodecomposition
of quinalphos by sunlight in water varied from 23 to 30
days and on soil surfaces from 2 to 5 days. |
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