| Identification | Back Directory | [Name]
(S)-PBMC
(PBMC) | [CAS]
1352138-54-5 | [Synonyms]
(S)-PBMC
(PBMC)
Carbamic acid, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, (1S)-1-phenylethyl ester | [Molecular Formula]
C26H30N2O4 | [MOL File]
1352138-54-5.mol | [Molecular Weight]
434.53 |
| Chemical Properties | Back Directory | [Boiling point ]
584.6±50.0 °C(Predicted) | [density ]
1.165±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C (des.) | [solubility ]
Soluble in DMSO (up to 30 mg/ml). | [form ]
oil | [pka]
9.17±0.10(Predicted) | [color ]
Light brown | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
PBMC (1352138-54-5) is a potent and selective blocker of TRPM8 channels. PBMC blocks both chemical and thermal activation of TRPM8.1?Reverses the menthol and cold-induced facilitation of the micturition reflex.2?PBMC represents a new lead for analgesic drugs based on blocking TRPM8.3 | [References]
1) Knowlton et al. (2011), Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice; PLoS One, 6(9) e25894
2) Gardiner et al. (2014), The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist; Eur. J. Pharmacol., 740 398
3) Salat et al. (2013), Transient receptor potential channels – emerging novel drug targets for the treatment of pain; Curr. Med. Chem., 20 1409 |
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