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ChemicalBook--->CAS DataBase List--->472981-92-3

472981-92-3

472981-92-3 Structure

472981-92-3 Structure
IdentificationBack Directory
[Name]

4'-CHLORO-3-METHOXYCINNAMANILIDE
[CAS]

472981-92-3
[Synonyms]

SB 366791
SB366791, >98%
SB 366791;SB366791
4'-CHLORO-3-METHOXYCINNAMANILIDE
N-(3-METHOXYPHENYL)-4-CHLOROCINNAMIDE
3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
(E)-3-(4-CHLOROPHENYL)-N-(3-METHOXYPHENYL)ACRYLAMIDE
2-Propenamide,3-(4-chlorophenyl)-N-(3-methoxyphenyl)-
[Molecular Formula]

C16H14ClNO2
[MDL Number]

MFCD01033818
[MOL File]

472981-92-3.mol
[Molecular Weight]

287.74
Chemical PropertiesBack Directory
[Melting point ]

165-167℃
[storage temp. ]

Store at RT
[solubility ]

DMSO: 13 mg/mL, soluble
[form ]

solid
[color ]

off-white
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
[HS Code ]

2924.29.7790
Hazard InformationBack Directory
[Description]

SB-366791 (472981-92-3) is a potent (IC50 = 0.7 μM) and selective TRPV1 blocker.1,2 Selective for TRPV1 in a panel of 47 different binding assays.
[Uses]

A potent and selective vanilloid receptor (TRPV1) antagonist. An effective antagonist of hTRPV1 when stimulated by capsaicin, acid, or noxious heat.
[Definition]

ChEBI: 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.
[Biological Activity]

Potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA 2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB 1 and CB 2 receptors, voltage-gated Ca 2+ channels and the hyperpolarization-activated current (I h ). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
[Biochem/physiol Actions]

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.
[storage]

Store at RT
[References]

1) Gunthorpe, et al., (2004) Identification and characterization of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist; Neuropharmacology 46 133 2) Varga et al. (2005) Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat; Neurosci. Lett.. 385 137
Spectrum DetailBack Directory
[Spectrum Detail]

4'-CHLORO-3-METHOXYCINNAMANILIDE(472981-92-3)1HNMR
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