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ChemicalBook--->CAS DataBase List--->1337482-15-1

1337482-15-1

1337482-15-1 Structure

1337482-15-1 Structure
IdentificationBack Directory
[Name]

Sofosbuvir IMpurity C
[CAS]

1337482-15-1
[Synonyms]

Ofosbuvi rimpurity
Sofosbuvir impurity G
sofosbuvir impurity Y008005-G
Sofosbuvir IMpurity C 1337482-15-1
Sofosbuvir 5'-Desphosphate 3’-O-[(S)-Phosphate]
L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-3'-uridylyl]-, 1-methylethyl ester
isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosph
isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alanite
isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate
(2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate
Sofosbuvir impurity 18/Sofosbuvir 3'-O-Phosphoramidate/Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate
[Molecular Formula]

C22H29FN3O9P
[MDL Number]

MFCD31560495
[MOL File]

1337482-15-1.mol
[Molecular Weight]

529.45
Chemical PropertiesBack Directory
[density ]

1.41±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

soluble in No data available
[form ]

Solid
[pka]

9.39±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Sofosbuvir 5''-Desphosphate 3''-O-[(S)-Phosphate] is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
[storage]

Store at -20°C
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