| Identification | Back Directory | [Name]
PSI-7977-13C-d3 | [CAS]
2070009-25-3 | [Synonyms]
PSI-7977-13C-d3
[13C,2H3]-Sofosbuvir
isopropyl((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-(methyl-13C-d3)tetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate | [Molecular Formula]
C2113CH26D3FN3O9P |
| Hazard Information | Back Directory | [Description]
PSI-7977-13C-d3 is intended for use as an internal standard for the quantification of PSI-7977 (Item No. 15402) by GC- or LC-MS. PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).1,2,3 PSI-7977 is effective in vitro and in vivo.2,4,5 | [Uses]
PSI-7977-13CD3 is the isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. |
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| Company Name: |
MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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