Identification | More | [Name]
Diethyl butylmalonate | [CAS]
133-08-4 | [Synonyms]
BMDE BUTYLMALONIC ACID DIETHYL ESTER DIETHYL BUTYLMALONATE DIETHYL N-BUTYLMALONATE ETHYL BUTYLMALONATE LABOTEST-BB LTBB001318 N-BUTYL DIETHYL MALONATE N-BUTYLMALONIC ACID DIETHYL ESTER N-BUTYMALONIC ACID DIETHYL ESTER 2-butyl-malonicaciddiethylester butyl-propanedioicaciddiethylester Diethyl 2-butylmalonate Diethyl normal-butylmalonate Malonic acid, butyl-, diethyl ester Propanedioic acid, butyl-, diethyl ester Propanedioicacid,butyl-,diethylester n-Butylammonic acid diethyl ester n-Butylmalonsurediethylester BUTYLMALONIC ESTER Diethyl 2-butylpropanedioate | [EINECS(EC#)]
205-089-1 | [Molecular Formula]
C11H20O4 | [MDL Number]
MFCD00009170 | [Molecular Weight]
216.27 | [MOL File]
133-08-4.mol |
Chemical Properties | Back Directory | [Appearance]
CLEAR COLOURLESS LIQUID | [Melting point ]
238 °C | [Boiling point ]
235-240 °C (lit.) | [density ]
0.983 g/mL at 25 °C(lit.)
| [vapor pressure ]
1Pa at 20℃ | [refractive index ]
n20/D 1.422(lit.)
| [Fp ]
201 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [pka]
13.47±0.46(Predicted) | [Specific Gravity]
0.975 (20/4℃) | [Water Solubility ]
330mg/L at 20℃ | [Merck ]
14,1576 | [BRN ]
608785 | [CAS DataBase Reference]
133-08-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Diethyl butylmalonate(133-08-4) |
Questions And Answer | Back Directory | [Synthesis]
Diethyl malonate is mixed with sodium ethoxide, and then chlorobutane is added to form the reaction. The crude product is separated and recovered ethanol, washed and dehydrated to obtain Diethyl butylmalonate. |
Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLOURLESS LIQUID | [Uses]
Diethyl 2-n-Butylmalonate is used as a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria. | [Synthesis Reference(s)]
Organic Syntheses, Coll. Vol. 1, p. 250, 1941 The Journal of Organic Chemistry, 44, p. 3492, 1979 DOI: 10.1021/jo01334a009 | [General Description]
Diethyl malonate (DEM) undergoes alkylation by ethyliodide, which is used to study the phase transfer catalysis (PTC) technique. | [Flammability and Explosibility]
Notclassified |
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