| Identification | More | [Name]
Pheniramine maleate | [CAS]
132-20-7 | [Synonyms]
1-phenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
2-[ALPHA-(2-DIMETHYLAMINOETHYL) BENZYL]PYRIDINE MALEATE SALT
PHENIRAMINE MALEATE
PHENIRAMINE MALEATE SALT
PHENIRAMIN MALEATE
PROPHENPYRIDAMINE MALEATE
1-(n,n-dimethylamino)-3-(phenyl-3-alpha-pyridyl)propanemaleate
2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine,bimaleate
2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine,maleate
2-(alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)
avil-retard
daneral
ho11513
inhiston
n,n-dimethyl-gamma-phenyl-2-pyridinepropanamin(z)-2-butenedioate(1:1)
pheniraminehydrogenmaleate
phenyl(2-pyridyl)(beta-n,n-dimethylaminomethyl)methanemaleate
pm241
trimetonmaleate
2-Pyridinepropanamine, N,N-dimethyl-.gamma.-phenyl-, (2Z)-2-butenedioate (1:1) | [EINECS(EC#)]
205-051-4 | [Molecular Formula]
C20H24N2O4 | [MDL Number]
MFCD00079250 | [Molecular Weight]
356.42 | [MOL File]
132-20-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
104-108°C | [Boiling point ]
489.25°C (rough estimate) | [density ]
1.2233 (rough estimate) | [refractive index ]
1.6800 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. | [form ]
neat | [color ]
White | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
>=1 g/100 mL at 24 ºC | [λmax]
262nm(lit.) | [Merck ]
14,7235 | [CAS DataBase Reference]
132-20-7(CAS DataBase Reference) | [EPA Substance Registry System]
132-20-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
UT0175000
| [HS Code ]
2933399090 |
| Hazard Information | Back Directory | [General Description]
White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic. | [Reactivity Profile]
PHENIRAMINE MALEATE(132-20-7) gives weakly acidic aqueous solutions. May react with strong oxidizing agents. | [Air & Water Reactions]
Water soluble. | [Fire Hazard]
Flash point data are not available for this chemical, but PHENIRAMINE MALEATE is probably combustible. | [Chemical Properties]
white powder | [Originator]
Trimeton Maleate, Schering ,US,1948 | [Uses]
A H1 histamine receptor antagonist. | [Uses]
Antihistaminic;H1 antagonist | [Uses]
Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria. | [Uses]
Used medicinally as an antihistaminic (merck). | [Definition]
ChEBI: Pheniramine maleate is an organic molecular entity. | [Manufacturing Process]
According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid. | [Therapeutic Function]
Antihistaminic | [Biochem/physiol Actions]
Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions. |
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