| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: slightly soluble; Methanol: slightly soluble | [form ]
Yellow powder. |
| Hazard Information | Back Directory | [Description]
Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1, and 6.3 μg/ml, respectively). It is cytotoxic to B16/F10 and Moser cells (IC50s = 0.0008 and 0.04 μg/ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM). | [Uses]
Quinaldopeptin is a symmetrical, cyclic decapeptide from an Amycolatopsis sp. that is a bis-intercalator of DNA, exhibiting strong in vitro antimicrobial and cytotoxic activity. Quinaldopeptin significantly prolongs the survival time of mice inoculated with a murine tumour, and also shows weak nematocidal activity. Quinaldopeptin is related to the luzopeptins and sandramycin. |
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| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Tebu-bio
|
| Tel: |
|
| Website: |
www.tebu-bio.com |
| Company Name: |
Alexis Corporation
|
| Tel: |
+41 61 926 8989 |
| Website: |
www.alexis-biochemicals.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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