| Identification | More | [Name]
KN-62 | [CAS]
127191-97-3 | [Synonyms]
KN-2
N 62
KN-62
CS-756
KN-62 97%
KN-62,97%
KN 62;KN-2
KN 62; KN62
KN-62, 99+%
KN-62, >=98%
KN-62 USP/EP/BP
KN-62;KN 62; KN62
KN-62 - CAS 127191-97-3 - Calbiochem
1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-*N-M ETHYL-L-TYR
(S)-4-(2-(N-Methylisoquinoline-5-sulfonaMido)-3-oxo-3-(4-phenylp
1-[N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL]-4-PHENYLPIPERAZINE
(1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL)4-PHENYLPIPERAZINE) KN 62
(S)-4-(2-(N-Methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl is
(S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonat
(S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate
(S)-4-(2-(N-methylisoquinoline-5-suNLFonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-suNLFonate
4-((2S)-2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenylisoquinolinesulfonicacid
[4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate
4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester
5-Isoquinolinesulfonicacid,4-[2-[(5-isoquinolinylsulfonyl)MethylaMino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylester, (S)-
4-[(2S)-2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]-3-OXO-3-(4-PHENYL-1-PIPERAZINYL)PROPYL] PHENYL ISOQUINOLINESULFONIC ACID ESTER
(s)-5-isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
(S)-5-ISOQUINOLINESULFONIC ACID 4-(2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]- 3-OXO-3-[4-PHENYL-1-PIPERAZINYL]PROPYL)PHENYL ESTER
5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
5-Isoquinolinesulfonic acid 4-[(S)-2-[[(isoquinolin-5-yl)sulfonyl]methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
noncompetitive antagonism,KN-62,KN 62,inhibit,P2XRs,Calmodulin-dependent protein kinases,HEK293 cells,P2X Receptor,Calmodulin-dependent kinases,CaMK,Inhibitor,autophosphorylation,KN62
4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-
3-(4-phenyl-1-piperazinyl)propyl]phenylisoquinolinesulfonicacid ester KN-62
1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl)phenyl Ester,
(S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine | [Molecular Formula]
C38H35N5O6S2 | [MDL Number]
MFCD00083180 | [Molecular Weight]
721.84 | [MOL File]
127191-97-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
92-94°C | [Boiling point ]
964.7±75.0 °C(Predicted) | [density ]
1.388 | [storage temp. ]
−20°C
| [solubility ]
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
| [form ]
solid
| [pka]
4.07±0.13(Predicted) | [color ]
white
| [Usage]
A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II | [CAS DataBase Reference]
127191-97-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II | [Uses]
It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM). | [Uses]
selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II, | [Definition]
ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines. | [General Description]
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner. | [Biological Activity]
Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ . | [Biochem/physiol Actions]
Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II. | [storage]
-20°C (desiccate) |
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