| Identification | Back Directory | [Name]
RO-31-7549 | [CAS]
125313-65-7 | [Synonyms]
RO-31-7549
RO 31-7549 ACETATE SALT
Bisindolylmaleimide VIII
BISINDOLYLMALEIMIDE VIII ACETATE
BIDINDOLYLMALEIMIDE VIII, ACETETE
Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem
2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE
3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)- | [Molecular Formula]
C24H22N4O2 | [MOL File]
125313-65-7.mol | [Molecular Weight]
398.46 |
| Hazard Information | Back Directory | [Uses]
It is a potent inhibitor of protein kinase C (PKC) activity. | [General Description]
A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM). | [Biochem/physiol Actions]
Cell permeable: yes |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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