| Identification | More | [Name]
Bisindolylmaleimide V | [CAS]
113963-68-1 | [Synonyms]
1-METHYL-3,4-BIS(3-INDOLYL)MALEIMIDE
1-METHYL-3,4-BIS(INDOL-3-YL)MALEIMIDE
2,3-BIS(1H-INDOL-3-YL)-N-METHYLMALEIMIDE
BISINDOLYLMALEIMIDE V
RO 31-6045
3,4-BIS-(1H-INDOL-3-YL)-1-METHYL-PYRROLE-2,5-DIONE
3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione
1-Methyl-3,4-bis(indol-3-yl)maleimide, Ro 31-6045
1-Methyl 3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione
1-Methyl-3-(1H-indole-3-yl)-4-(1H-indole-3-yl)-1H-pyrrole-2,5-dione
1-Methyl-3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione
3,4-Bis(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione
3,4-Bis(1H-indole-3-yl)-1-methyl-3-pyrroline-2,5-dione | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C21H17N3O2 | [MDL Number]
MFCD00236433 | [Molecular Weight]
343.38 | [MOL File]
113963-68-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
>260 °C | [Boiling point ]
655.7±55.0 °C(Predicted) | [density ]
1.450±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMSO: soluble
| [form ]
solid
| [pka]
15.89±0.30(Predicted) | [color ]
Orange | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | [CAS DataBase Reference]
113963-68-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4. | [Definition]
ChEBI: Ro 31-6045 is a member of indoles. | [References]
1) Marmy-Conus?et al.?(2002),?Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett.,?519?135
2) Harmon?et al.?(1997),?Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol.,?10?71
3) Toullec?et al.?(1991),?The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem.,?266?15771
4) Davis?et al. (1992),?Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem.,?35?177 |
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