| Identification | Back Directory | [Name]
(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one | [CAS]
123367-26-0 | [Synonyms]
Irutinib Impurity A
Imatinib impurity J
(E)-3-(dimethylamino)
Imatinib EP impuritiesA
Imatinib Mesilate Impurity A
Imatinib Mesilate EP Impurity A
Imatinib EP Impurity A (Nilotinib Impurity 16)
Nilotinib Impurity 16 (Imatinib EP Impurity A)
(E)-3-(Dimethylamino)-1-(3-pyridyl)-2-propen-1-one
(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one
(E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
(2E)-3-(DiMethylaMino)-1-(pyridin-3-yl)prop-2-en-1-one
2-Propen-1-one, 3-(dimethylamino)-1-(3-pyridinyl)-, (2E)-
Nilotinib IMpurity ((2E)-3-(DiMethylaMino)-1-(3-pyridyl)prop-2-en-1-one)
Imatinib impurity 14/(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
(2E)-3-(DiMethylaMino)-1-(3-pyridyl)prop-2-en-1-one (IMpurity of Nilotinib) | [Molecular Formula]
C10H12N2O | [MDL Number]
MFCD00115180 | [MOL File]
123367-26-0.mol | [Molecular Weight]
176.22 |
| Chemical Properties | Back Directory | [Melting point ]
113℃ | [Boiling point ]
281℃ | [density ]
1.070 | [Fp ]
124℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.74±0.70(Predicted) | [color ]
Dark Brown to Very Dark Brown |
| Hazard Information | Back Directory | [Description]
(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one is a pharmaceutical intermediate used as an intermediate of nilotinib, a targeted anticancer drug for the treatment of chronic myeloid leukaemia (CML). | [Uses]
(2E)?-?3-?(Dimethylamino)?-?1-?(3-?pyridyl)?prop-?2-?en-?1-?one acts as a reagent for the synthesis of oxindole-linked indolyl-pyrimidine derivatives which are potential cytotoxic agents. | [Solubility in organics]
(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one is soluble in chloroform and dichloromethane. |
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