| Identification | More | [Name]
Glycidyl phenyl ether | [CAS]
122-60-1 | [Synonyms]
1,2-EPOXY-3-PHENOXYPROPANE
1,2-EPOXYETHYL PHENYL ETHER
1-PHENOXY-2,3-PROPYLENE OXIDE
2,3-EPOXYPROPYL PHENYL ETHER
2-(PHENOXYMETHYL)OXIRANE
GLYCIDYL PHENYL ETHER
PGE
PHENYL 2,3-EPOXYPROPYL ETHER
PHENYL GLYCID ETHER
PHENYL GLYCIDYL ETHER
Phenyl tlycidyl ether
(2,3-epoxypropoxy)-benzen
(2,3-epoxypropoxy)benzene
(phenoxymethyl)-oxiran
(Phenoxymethyl)oxirane
(phenoxymethyl)-Oxirane
1,2-epoxy-3-phenoxy-propan
1-Phenoxy-2,3-epoxypropane
2,3-Epoxy-1-phenoxypropane
2,3-Epoxypropoxybenzene | [EINECS(EC#)]
204-557-2 | [Molecular Formula]
C9H10O2 | [MDL Number]
MFCD00005133 | [Molecular Weight]
150.17 | [MOL File]
122-60-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Phenyl glycidyl ether is a colorless liquid with an unpleasant sweet odor | [Melting point ]
3.5 °C(lit.)
| [Boiling point ]
245-247 °C(lit.)
| [density ]
1.109 g/mL at 25 °C(lit.)
| [vapor density ]
5.2 (vs air)
| [vapor pressure ]
0.03 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.531
| [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
2.4g/l | [form ]
Liquid | [color ]
Clear colorless to yellow | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
2.4 g/L (20 ºC) | [BRN ]
2744 | [Exposure limits]
TLV-TWA 6 mg/m3
(1 ppm) (ACGIH);
1 ppm (15 min) (NIOSH). | [Contact allergens]
This monoglycidyl derivative is a reactive diluent in
epoxy resins Bisphenol A type. It is a component of
epoxy paints, epoxy glues, and epoxy resins.
Sensitization has been observed in many professions,
such as in construction workers, marble workers,
ceramic workers, and shoemakers. | [InChIKey]
FQYUMYWMJTYZTK-UHFFFAOYSA-N | [LogP]
1.61 at 25℃ | [CAS DataBase Reference]
122-60-1(CAS DataBase Reference) | [IARC]
2B (Vol. 47, 71) 1999 | [NIST Chemistry Reference]
Oxirane, (phenoxymethyl)-(122-60-1) | [EPA Substance Registry System]
122-60-1(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
colourless liquid | [General Description]
Colorless liquid. | [Reactivity Profile]
PHENYL GLYCIDYL ETHER(122-60-1), an ether, can act as a base. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. | [Air & Water Reactions]
Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Slightly soluble in water. | [Potential Exposure]
PGE is used to increase storage time and stability of halogenated compounds; as a reactive diluent in uncured epoxy resins to reduce the viscosity of the uncured system for ease in casting; adhesive, and laminating applications. NIOSH once estimated that 8000 workers are potentially exposed to PGE. | [Fire Hazard]
This chemical is probably combustible. | [First aid]
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. | [Shipping]
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. | [Incompatibilities]
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, amines, and curing agents. PGE can presumably form explosive peroxides | [Description]
This monoglycidyl derivative is a reactive diluent in
epoxy resins of the bisphenol A type. It is a component
of epoxy paints, epoxy glues, and epoxy resins.
Sensitization was observed in many professions, such
as in construction workers, marble workers, ceramic
workers, and in a shoemaker. | [Waste Disposal]
Concentrated waste containing no peroxides-discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxidesperforation of a container of the waste from a safe distance followed by open burning. | [Uses]
2-Phenylglycidyl ether is an organic synthesis; chemical intermediate with high solvency for halogenated materials; reactive diluent of epoxy-resin systems; forms chemical bonds with the resin during cure and accelerates the curing process. | [Uses]
Chemical intermediate with high solvency
for halogenated materials | [Uses]
Phenyl glycidyl ether (PGE) is used as anintermediate in organic syntheses. | [Definition]
ChEBI: Phenyl glycidyl ether is an aromatic ether. | [Production Methods]
PGE is synthesized by condensation of phenol with epichlorohydrin,
with subsequent dehydrochlorination with caustic
to form the epoxy ring. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 50, p. 1784, 1985 DOI: 10.1021/jo00210a053 | [Health Hazard]
PGE is a toxic compound exhibiting moderate irritant action and carcinogenicity inanimals. Application of 0.25 mg resulted insevere eye irritation in rabbits, while 500 mgcaused moderate skin irritation over a periodof 24 hours. Prolonged or repeated contactcan cause moderate irritation and skin sensitization in humans.
The symptoms of its toxicity in animalswere depression of the central nervous system and paralysis of the respiratory tract.Prolonged exposure caused changes in thekidney, liver, thymus, and testes, and lossof hair in rats. The toxicity of this compound in humans is low and the health hazardcan arise primarily from its skin-sensitizationaction.
LD50 value, oral (mice): 1400 mg/kg
DGE showed carcinogenicity in rats, causingnasal cancer. | [Carcinogenicity]
Chronic exposure of rats to 1 or 12ppm
6 hours/day, 5 days/week for 2 years caused an
increased incidence of rhinitis, squamous metaplasia,
and epidermal carcinomas of the nasal
cavity.4 The IARC has determined that there is
sufficient evidence for the carcinogenicity of
PGE in animals and that it is possibly carcinogenic
to humans. |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R45:May cause cancer.
R20:Harmful by inhalation.
R37/38:Irritating to respiratory system and skin .
R43:May cause sensitization by skin contact.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R68:Possible risk of irreversible effects. | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
2810 | [WGK Germany ]
3
| [RTECS ]
TZ3675000
| [Autoignition Temperature]
430 °C | [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29109000 | [Safety Profile]
Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion, skin contact, and subcutaneous routes. A severe eye and skin irritant. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a chemical intermediate. See also ETHERS | [Hazardous Substances Data]
122-60-1(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 2150 mg/kg LD50 dermal Rabbit 1500 mg/kg | [IDLA]
100 ppm |
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