| Identification | More | [Name]
Triethyl orthoformate | [CAS]
122-51-0 | [Synonyms]
1,1,1-TRIETHOXYMETHANE
AETHON
AKOS BBS-00004276
ETHONE
ETHYL-O-FORMATE
ETHYL ORTHOFORMATE
ORTHOFORMIC ACID TRIETHYL ESTER
TEOF
TRIETHOXYMETHANE
TRIETHYL-O-FORMATE
TRIETHYL ORTHOFORMATE
1-(Diethoxymethoxy)ethane
1,1',1'-(Methylidynetris(oxy))tris(ethane)
1,1’,1’-(methylidynetris(oxy))tris(ethane)
1,1’,1’’-[methylidynetris(oxy)]tris-ethan
1,1’,1’’-[methylidynetris(oxy)]tris-Ethane
Ethane, 1,1',1''-[methylidynetris(oxy)]tris-
Ethane,1,1’,1’’-[methylidynetris(oxy)]tris-
Ethyl formate(ortho)
Ethylester kyseliny orthomravenci | [EINECS(EC#)]
204-550-4 | [Molecular Formula]
C7H16O3 | [MDL Number]
MFCD00009230 | [Molecular Weight]
148.2 | [MOL File]
122-51-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol,
ether; decomposes in water. | [Melting point ]
-76 °C (lit.) | [Boiling point ]
146 °C (lit.) | [density ]
0.891 g/mL at 25 °C(lit.)
| [vapor density ]
5.11 (vs air)
| [vapor pressure ]
2.9 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.391(lit.)
| [Fp ]
86 °F
| [storage temp. ]
Flammables area | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Liquid | [color ]
Clear colorless | [Water Solubility ]
1.35 g/L | [Sensitive ]
Moisture Sensitive | [Merck ]
14,6884 | [BRN ]
605384 | [Stability:]
Moisture Sensitive | [InChIKey]
GKASDNZWUGIAMG-UHFFFAOYSA-N | [LogP]
1.2 at 20℃ | [CAS DataBase Reference]
122-51-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethyl orthoformate(122-51-0) | [EPA Substance Registry System]
Ethyl orthoformate (122-51-0) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R10:Flammable.
R36:Irritating to the eyes.
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2524 3/PG 3
| [WGK Germany ]
1
| [RTECS ]
RM6475000
| [F ]
21 | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29159080 | [Safety Profile]
Moderately toxic by
ingestion. Mddly toxic by inhalation, skin
contact, and subcutaneous routes. A skin
and eye irritant. A very dangerous fire
hazard when exposed to heat or flame; can
react vigorously with oxidzing materials. To
fight fire, use foam, CO2, dry chemical.
When heated to decomposition it emits
acrid smoke and irritating fumes. See also
ESTERS. | [Toxicity]
LD50 orally in rats: 7.06 g/kg (Smyth) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ethanol-->Sodium-->Chloroform-->Sodium ethoxide-->Benzoyl chloride-->Sodium ethylate solution,in ethyl alcohol | [Preparation Products]
3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE-->1-CYCLOHEXYLURACIL-->METHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE-->1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE-->4-Acetylphenylboronic acid-->4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE-->1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97%-->2-Formylfuran-5-boronic acid-->Estazolam-->2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID-->4-Methylpyrimidine-->2-AMINO-3,5-DICYANOPYRIDINE-->ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE-->4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)--->1-CHLORO-4-ISOCYANOBENZENE-->4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER-->ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE-->2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE-->Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate-->Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate-->4-Chloro-7-(trifluoromethyl)quinoline-->4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER-->ETHYL 4-CHLORO-6-(TRIFLUOROMETHYL)-3-QUINOLINECARBOXYLATE-->2-HYDROXY-4-METHYLPYRIMIDINE-5-CARBOXYLIC ACID-->Diethoxymethyl acetate-->3-Aminopyrazole-4-carboxylic acid-->ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE-->5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE-->2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID-->5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE-->ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE-->5-CARBETHOXYURACIL-->3-(2-FLUOROBENZYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE-->N-FORMYLGLYCINE ETHYL ESTER-->4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE-->2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE-->4,5-Dicyanoimidazole-->Chloromethyltriethoxysilane |
| Hazard Information | Back Directory | [General Description]
A clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals. | [Reactivity Profile]
ETHYL ORTHOFORMATE(122-51-0) is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. | [Air & Water Reactions]
Highly flammable. Slightly soluble in water. | [Hazard]
Flammable, moderate fire risk. | [Health Hazard]
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. | [Fire Hazard]
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. | [Chemical Properties]
Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol,
ether; decomposes in water. | [Uses]
A reagent useful for acetylization and imidic ester formation. | [Uses]
Labelled Prednisolone 21-Sulfate (P703755). Prednisolone 21-Sulfate is a metabolite of Prednisolone (P703740). | [Application]
Sweet, somewhat camphoraceous-herbaceous odor with a Fimecdle-like note.
Triethyl orthoformate has been suggested for use in industrial
fragrances for masking, etc. and may find
some application in that field. It tends to lift
the odor of the conventional components of a
pine fragrance and increase the radiation, an
effect often desirable for masking purposes. | [Flammability and Explosibility]
Flammable | [Purification Methods]
Fractionate it first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column (p 11). [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE. |
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